Y-chromosome E Haplogroups: Their Distribution and Implication to the Origin of Afro-Asiatic Languages and Pastoralism

Overview

Journal Eur J Hum Genet

Specialty Genetics

Date 2014 Mar 27

PMID 24667790

Citations 4

Authors

Eyoab I Gebremeskel

Muntaser E Ibrahim

Affiliations

Soon will be listed here.

Abstract

Archeological and paleontological evidences point to East Africa as the likely area of early evolution of modern humans. Genetic studies also indicate that populations from the region often contain, but not exclusively, representatives of the more basal clades of mitochondrial and Y-chromosome phylogenies. Most Y-chromosome haplogroup diversity in Africa, however, is present within macrohaplogroup E that seem to have appeared 21 000-32 000 YBP somewhere between the Red Sea and Lake Chad. The combined analysis of 17 bi-allelic markers in 1214 Y chromosomes together with cultural background of 49 populations displayed in various metrics: network, multidimensional scaling, principal component analysis and neighbor-joining plots, indicate a major contribution of East African populations to the foundation of the macrohaplogroup, suggesting a diversification that predates the appearance of some cultural traits and the subsequent expansion that is more associated with the cultural and linguistic diversity witnessed today. The proto-Afro-Asiatic group carrying the E-P2 mutation may have appeared at this point in time and subsequently gave rise to the different major population groups including current speakers of the Afro-Asiatic languages and pastoralist populations.

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References

Cinnioglu C, King R, Kivisild T, Kalfoglu E, Atasoy S, Cavalleri G . Excavating Y-chromosome haplotype strata in Anatolia. Hum Genet. 2003; 114(2):127-48. DOI: 10.1007/s00439-003-1031-4. View

Mendez F, Krahn T, Schrack B, Krahn A, Veeramah K, Woerner A . An African American paternal lineage adds an extremely ancient root to the human Y chromosome phylogenetic tree. Am J Hum Genet. 2013; 92(3):454-9. PMC: 3591855. DOI: 10.1016/j.ajhg.2013.02.002. View

Sanchez J, Hallenberg C, Borsting C, Hernandez A, Morling N . High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males. Eur J Hum Genet. 2005; 13(7):856-66. DOI: 10.1038/sj.ejhg.5201390. View

Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S . MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011; 28(10):2731-9. PMC: 3203626. DOI: 10.1093/molbev/msr121. View

. A nomenclature system for the tree of human Y-chromosomal binary haplogroups. Genome Res. 2002; 12(2):339-48. PMC: 155271. DOI: 10.1101/gr.217602. View

Mellars P . Why did modern human populations disperse from Africa ca. 60,000 years ago? A new model. Proc Natl Acad Sci U S A. 2006; 103(25):9381-6. PMC: 1480416. DOI: 10.1073/pnas.0510792103. View

Scozzari R, Cruciani F, Malaspina P, Santolamazza P, Ciminelli B, Torroni A . Differential structuring of human populations for homologous X and Y microsatellite loci. Am J Hum Genet. 1997; 61(3):719-33. PMC: 1715969. DOI: 10.1086/515500. View

Fadhlaoui-Zid K, Plaza S, Calafell F, Ben Amor M, Comas D, Bennamar El gaaied A . Mitochondrial DNA heterogeneity in Tunisian Berbers. Ann Hum Genet. 2004; 68(Pt 3):222-33. DOI: 10.1046/j.1529-8817.2004.00096.x. View

Underhill P, Shen P, Lin A, Jin L, Passarino G, Yang W . Y chromosome sequence variation and the history of human populations. Nat Genet. 2000; 26(3):358-61. DOI: 10.1038/81685. View

10.

Fernandes V, Alshamali F, Alves M, Costa M, Pereira J, Silva N . The Arabian cradle: mitochondrial relicts of the first steps along the southern route out of Africa. Am J Hum Genet. 2012; 90(2):347-55. PMC: 3276663. DOI: 10.1016/j.ajhg.2011.12.010. View

11.

Luis J, Rowold D, Regueiro M, Caeiro B, Cinnioglu C, Roseman C . The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations. Am J Hum Genet. 2004; 74(3):532-44. PMC: 1182266. DOI: 10.1086/382286. View

12.

Wei W, Ayub Q, Chen Y, McCarthy S, Hou Y, Carbone I . A calibrated human Y-chromosomal phylogeny based on resequencing. Genome Res. 2012; 23(2):388-95. PMC: 3561879. DOI: 10.1101/gr.143198.112. View

13.

Scozzari R, Massaia A, DAtanasio E, Myres N, Perego U, Trombetta B . Molecular dissection of the basal clades in the human Y chromosome phylogenetic tree. PLoS One. 2012; 7(11):e49170. PMC: 3492319. DOI: 10.1371/journal.pone.0049170. View

14.

Chiaroni J, Underhill P, Cavalli-Sforza L . Y chromosome diversity, human expansion, drift, and cultural evolution. Proc Natl Acad Sci U S A. 2009; 106(48):20174-9. PMC: 2787129. DOI: 10.1073/pnas.0910803106. View

15.

Cavalli-Sforza L . Genes, peoples, and languages. Proc Natl Acad Sci U S A. 1997; 94(15):7719-24. PMC: 33682. DOI: 10.1073/pnas.94.15.7719. View

16.

Arredi B, Poloni E, Paracchini S, Zerjal T, Fathallah D, Makrelouf M . A predominantly neolithic origin for Y-chromosomal DNA variation in North Africa. Am J Hum Genet. 2004; 75(2):338-45. PMC: 1216069. DOI: 10.1086/423147. View

17.

Cruciani F, La Fratta R, Santolamazza P, Sellitto D, Pascone R, Moral P . Phylogeographic analysis of haplogroup E3b (E-M215) y chromosomes reveals multiple migratory events within and out of Africa. Am J Hum Genet. 2004; 74(5):1014-22. PMC: 1181964. DOI: 10.1086/386294. View

18.

Underhill P, Passarino G, Lin A, Shen P, Lahr M, Foley R . The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Ann Hum Genet. 2001; 65(Pt 1):43-62. DOI: 10.1046/j.1469-1809.2001.6510043.x. View

19.

McEvoy B, Powell J, Goddard M, Visscher P . Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res. 2011; 21(6):821-9. PMC: 3106315. DOI: 10.1101/gr.119636.110. View

20.

Abu-Amero K, Hellani A, Gonzalez A, Larruga J, Cabrera V, Underhill P . Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions. BMC Genet. 2009; 10:59. PMC: 2759955. DOI: 10.1186/1471-2156-10-59. View