Chronic Intraocular Inflammation and Development of Retinal Degenerative Disease

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2014 Mar 26

PMID 24664726

Citations 2

Authors

Charles E Egwuagu

Affiliations

Soon will be listed here.

Abstract

Elevated levels of inflammatory cytokines in the vitreous of patients with chronic intraocular inflammatory (uveitis) have long been suspected to contribute to the pathogenesis of retinal degenerative diseases. However, direct connection between chronic inflammation and development of retinal degenerative diseases has been difficult to establish because we lack an appropriate animal model of co-existing chronic intraocular inflammation and neurodegeneration. This report discusses new developments in immunological and diabetic research that suggest that persistent secretion of pro-inflammatory cytokines during uveitis might induce insulin resistance and retinal degenerative changes that contribute to the pathogenesis of Diabetic Retinopathy (DR), a retinal dystrophy of significant public health importance.

Citing Articles

The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice.

Nahomi R, Sampathkumar S, Myers A, Elghazi L, Smith D, Tang J Invest Ophthalmol Vis Sci. 2018; 59(5):2042-2053.

PMID: 29677366 PMC: 5908388. DOI: 10.1167/iovs.17-22702.

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?.

Ortiz G, Salica J, Chuluyan E, Gallo J Biol Res. 2015; 47:58.

PMID: 25723058 PMC: 4335423. DOI: 10.1186/0717-6287-47-58.

References

Meleth A, Agron E, Chan C, Reed G, Arora K, Byrnes G . Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2005; 46(11):4295-301. DOI: 10.1167/iovs.04-1057. View

Oh H, Yu C, Lee Y, Chan C, Maminishkis A, Egwuagu C . Autoreactive memory CD4+ T lymphocytes that mediate chronic uveitis reside in the bone marrow through STAT3-dependent mechanisms. J Immunol. 2011; 187(6):3338-46. PMC: 3304102. DOI: 10.4049/jimmunol.1004019. View

Naka T, Fujimoto M, Kishimoto T . Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. Trends Biochem Sci. 1999; 24(10):394-8. DOI: 10.1016/s0968-0004(99)01454-1. View

Antonetti D, Barber A, Bronson S, Freeman W, Gardner T, Jefferson L . Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 2006; 55(9):2401-11. DOI: 10.2337/db05-1635. View

Emanuelli B, Glondu M, Filloux C, Peraldi P, Van Obberghen E . The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells. Diabetes. 2004; 53 Suppl 3:S97-S103. DOI: 10.2337/diabetes.53.suppl_3.s97. View

Hilton D . Negative regulators of cytokine signal transduction. Cell Mol Life Sci. 1999; 55(12):1568-77. PMC: 11146996. DOI: 10.1007/s000180050396. View

Taniguchi C, Emanuelli B, Kahn C . Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006; 7(2):85-96. DOI: 10.1038/nrm1837. View

Egwuagu C, Mahdi R, Chan C, Sztein J, Li W, Smith J . Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats. Clin Immunol. 1999; 91(2):196-205. DOI: 10.1006/clim.1999.4701. View

Nussenblatt R . Proctor Lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest Ophthalmol Vis Sci. 1991; 32(13):3131-41. View

10.

Liu X, Lee Y, Yu C, Egwuagu C . Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J Immunol. 2008; 180(9):6070-6. PMC: 2435016. DOI: 10.4049/jimmunol.180.9.6070. View

11.

Liu X, Mameza M, Lee Y, Eseonu C, Yu C, Kang Derwent J . Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells. Diabetes. 2008; 57(6):1651-8. PMC: 2756726. DOI: 10.2337/db07-1761. View

12.

Amadi-Obi A, Yu C, Liu X, Mahdi R, Clarke G, Nussenblatt R . TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med. 2007; 13(6):711-8. DOI: 10.1038/nm1585. View