Relationship Between P561T and C422F Polymorphisms in Growth Hormone Receptor Gene and Mandibular Prognathism

Overview

Journal Angle Orthod

Specialty Dentistry

Date 2014 Mar 25

PMID 24654940

Citations 15

Authors

Sinem Bayram

Faruk Ayhan Basciftci

Ercan Kurar

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the allele and genotype frequencies of the P561T and C422F polymorphic sites of the growth hormone receptor (GHR) gene and the relationship between mandibular prognathism (MP) and these two single-nucleotide polymorphisms (SNPs).

Materials And Methods: A total of 99 subjects with severe skeletal Class III MP who planned to undergo orthognathic surgery and 99 subjects with Class I occlusion were examined in this study to evaluate the relationship between MP and two SNPs in exon 10 of the GHR gene. GHR was chosen as a candidate gene because growth hormone plays an important role in cartilage growth. A blood sample was used to extract genomic DNA, and the polymerase chain reaction-restriction fragment length polymorphism method was used to determine genotypes of P561T and C422F. The Minitab 14.0 packet program was used to perform statistical analysis.

Results: Allele frequencies of the C422F and P561T variants were determined. Because of the low allele frequency of the control group, statistical analysis could not be performed to test the difference between MP and control groups. Therefore, the data were combined to determine the association between the P561T polymorphism and craniofacial measurements. Effective mandibular length (condylion-gnathion) and lower face height (anterior nasal spina-menton) were associated with the P561T variant.

Conclusion: This finding supports that the GHR might be a candidate gene for mandibular morphogenesis in this population.

Citing Articles

Craniofacial syndromes and class III phenotype: common genotype fingerprints? A scoping review and meta-analysis.

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East Asian and Southern European craniofacial class III phenotype: two sides of the same coin?.

Dehesa-Santos A, Park J, Lee S, Iglesias-Linares A Clin Oral Investig. 2024; 28(1):84.

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Polymorphism analysis of myosin 1H (G/A) and P561T (C/A) genes on class I, class II, and class III malocclusion.

Gullianne B, Jazaldi F, Soedarsono N, Soegiharto B J Orthod Sci. 2022; 11:36.

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The association of polymorphisms in and skeletal Class II div.1 maxillary and mandibular dimensions. A preliminary 'report.

Hussein A, Porntaveetus T, Abid M Saudi J Biol Sci. 2022; 29(10):103405.

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Analysis of Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism.

Atteeri A, Neela P, Mamillapalli P, Sesham V, Keesara S, Chandra J Glob Med Genet. 2021; 8(4):156-161.

PMID: 34877573 PMC: 8635817. DOI: 10.1055/s-0041-1731066.

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