Genome-wide Linkage Analysis of Mandibular Prognathism in Korean and Japanese Patients
Overview
Authors
Affiliations
The existence of familial aggregation of mandibular prognathism (MP) suggests that genetic components play an important role in its etiology. In this study, a genome-wide linkage analysis to identify loci susceptible to MP was conducted with 90 affected sibling-pairs in 42 families, comprised of 40 Korean sibling-pairs and 50 Japanese sibling-pairs. Two non-parametric linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to MP at chromosomes 1p36, 6q25, and 19p13.2. The best evidence of linkage was detected near D1S234 (maximum Z(lr) = 2.51, P = 0.0012). In addition, evidence of linkage was observed near D6S305 (maximum Z(lr) = 2.23, P = 0.025) and D19S884 (maximum Z(lr) = 1.93, P = 0.0089). Identification of the susceptible genes in the linkage regions will pave the way for insights into the molecular pathways that cause MP, especially overgrowth of the mandible, and may lead to the development of novel therapeutic tools.
Genetic factors underlying Mandibular prognathism: insights from recent human and animal studies.
Fang H, Li P, Zhu S, Bi R Mamm Genome. 2024; 36(1):293-305.
PMID: 39607497 DOI: 10.1007/s00335-024-10084-x.
Genetic Insights into Skeletal Malocclusion: The Role of the FBN3 SNP in the Romanian Population.
Toparcean A, Acatrinei A, Rusu I, Festila D, Campian R, Kelemen B Medicina (Kaunas). 2024; 60(7).
PMID: 39064490 PMC: 11279028. DOI: 10.3390/medicina60071061.
Almokri N, Alsaggaf D, Alsulaimani F, Zawawi K Contemp Clin Dent. 2023; 14(3):232-238.
PMID: 38075537 PMC: 10699194. DOI: 10.4103/ccd.ccd_220_23.
Lone I, Zohud O, Midlej K, Proff P, Watted N, Iraqi F J Clin Med. 2023; 12(15).
PMID: 37568550 PMC: 10420085. DOI: 10.3390/jcm12155148.
Missense polymorphisms potentially involved in mandibular prognathism.
Kalmari A, Hosseinzadeh Colagar A, Heydari M, Arash V J Oral Biol Craniofac Res. 2023; 13(3):453-460.
PMID: 37228872 PMC: 10203774. DOI: 10.1016/j.jobcr.2023.05.007.