Eosinophilic Granuloma with Splendore-Hoeppli Material Caused by Toxigenic Corynebacterium Ulcerans in a Heifer

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2014 Mar 18

PMID 24632861

Citations 7

Authors

Kenji Murakami

Eiji Hata

Shinichi Hatama

Yoshihiro Wada

Mitsuru Ito

Yoshiharu Ishikawa

Koichi Kadota

Affiliations

Soon will be listed here.

Abstract

Raised lesions were present on the left nasal vestibule of a 20-month-old Japanese Brown heifer. The largest mass which caused partial nasal obstruction was removed surgically. Corynebacterium ulcerans was identified in the mass. 16S ribosomal RNA and RNA polymerase beta subunit genes were 100% and 98% identical to other C. ulcerans strains. Histologically, multiple foci of eosinophilic granuloma with Splendore-Hoeppli material were seen. Rod-shaped Gram-positive organisms were detected with metachromatic granules, producing diphtheria toxin with 5, 30 and 48 amino acid differences to another C. ulcerans strain, C. diphtheriae or C. pseudotuberculosis, respectively. The toxin is highly cytotoxic and may be responsible for the formation of abundant Splendore-Hoeppli material. The lesion was therefore judged to be an allergic reaction to bacterial antigens or diphtheria toxin.

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