Oral Manifestations Resulting from Chemotherapy in Children with Acute Lymphoblastic Leukemia

Overview

Journal Braz J Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2014 Mar 15

PMID 24626896

Citations 15

Authors

Everton Freitas de Morais

Jadson Alexandre da Silva Lira

Romulo Augusto de Paiva Macedo

Klaus Steyllon dos Santos

Cassandra Teixeira Valle Elias

Maria de Lourdes Silva de Arruda Morais

Affiliations

Soon will be listed here.

Abstract

Introduction: Acute lymphocytic leukemia is a type of cancer most common in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.

Aim: Identify most frequent oral manifestations in children with acute lymphocytic leukemia under chemotherapy treatment.

Methodology: The research was conducted on the electronic database PubMed/Medline, Science Direct, Scielo and Scopus. It has been sought papers with full presentation, wrote in Portuguese, English and Spanish, published between January 1992 and April 2013.

Results: From studies primarily selected, only eight met the criteria of inclusion. All studies performed intraoral examinations to diagnose oral lesions. According to results, the most frequent lesions were mucositis, candidiasis, periodontitis and gingivitis. The oral health condition from acute lymphocytic leukemia carriers varied according oral hygiene of the patient.

Conclusion: The results of studies identified such a great part of patients with ALL presented some lesion in oral cavity during or after chemotherapy treatment. The dentist surgeon needs to recognize oral manifestations and intervene in the oral health of patients with ALL, contributing and helping with treatment.

Citing Articles

Assessment of the Changes in the Salivary Profile and Its Clinical Correlation in Children with Acute Lymphoblastic Leukemia Undergoing Chemotherapy: A Follow-up Study.

Paranjape M, Shah P, Patil S, Shah R, Jagtap C, Lakade L Int J Clin Pediatr Dent. 2024; 16(Suppl 3):268-271.

PMID: 38268631 PMC: 10804290. DOI: 10.5005/jp-journals-10005-2692.

Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis.

Pombo Lopes J, Rodrigues I, Machado V, Botelho J, Lopes L Cancers (Basel). 2024; 16(1).

PMID: 38201538 PMC: 10777916. DOI: 10.3390/cancers16010110.

Exploring the Impact of Blood Disorders on Dental Caries.

Kale G, Nelakurthi V, Paul P Cureus. 2023; 15(10):e47159.

PMID: 38021750 PMC: 10651806. DOI: 10.7759/cureus.47159.

Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.

Longo B, Rohling I, Silva P, de Morais M, Paz H, Casarin R Clin Oral Investig. 2023; 27(11):6637-6644.

PMID: 37735213 DOI: 10.1007/s00784-023-05270-1.

DNA Methyltransferase Genes Are Associated with Oral Mucositis and Creatinine Levels in Oncopediatric Patients.

de Souza B, Filho J, Queiroz Neto J, de Castro Coelho M, Valenca A, Persuhn D Genes (Basel). 2023; 14(6).

PMID: 37372315 PMC: 10298124. DOI: 10.3390/genes14061136.

References

Pels E, Mielnik-Blaszczak M . Oral hygiene in children suffering from acute lymphoblastic leukemia living in rural and urban regions. Ann Agric Environ Med. 2012; 19(3):529-33. View

Sonis S . Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol. 1998; 34(1):39-43. DOI: 10.1016/s1368-8375(97)00053-5. View

Ferretti G, Raybould T, Brown A, Macdonald J, Greenwood M, Maruyama Y . Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial. Oral Surg Oral Med Oral Pathol. 1990; 69(3):331-8. DOI: 10.1016/0030-4220(90)90295-4. View

Pereira Pinto L, de Souza L, Gordon-Nunez M, Soares R, Costa E, Aquino A . Prevention of oral lesions in children with acute lymphoblastic leukemia. Int J Pediatr Otorhinolaryngol. 2006; 70(11):1847-51. DOI: 10.1016/j.ijporl.2006.04.016. View

Ponce-Torres E, Ruiz-Rodriguez M, Alejo-Gonzalez F, Hernandez-Sierra J, Pozos-Guillen A . Oral manifestations in pediatric patients receiving chemotherapy for acute lymphoblastic leukemia. J Clin Pediatr Dent. 2010; 34(3):275-9. DOI: 10.17796/jcpd.34.3.y060151580h301t7. View

Soares A, Aquino A, de Carvalho C, Nonaka C, Almeida D, Pereira Pinto L . Frequency of oral mucositis and microbiological analysis in children with acute lymphoblastic leukemia treated with 0.12% chlorhexidine gluconate. Braz Dent J. 2011; 22(4):312-6. DOI: 10.1590/s0103-64402011000400009. View

Sonis A, Waber D, Sallan S, Tarbell N . The oral health of long-term survivors of acute lymphoblastic leukaemia: a comparison of three treatment modalities. Eur J Cancer B Oral Oncol. 1995; 31B(4):250-2. DOI: 10.1016/0964-1955(95)00022-a. View

Bensadoun R, Magne N, Marcy P, Demard F . Chemotherapy- and radiotherapy-induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment. Eur Arch Otorhinolaryngol. 2002; 258(9):481-7. DOI: 10.1007/s004050100368. View

Childers N, Stinnett E, Wheeler P, Wright J, Castleberry R, Dasanayake A . Oral complications in children with cancer. Oral Surg Oral Med Oral Pathol. 1993; 75(1):41-7. DOI: 10.1016/0030-4220(93)90404-r. View

10.

Hamerschlak N . Leukemia: genetics and prognostic factors. J Pediatr (Rio J). 2008; 84(4 Suppl):S52-7. DOI: 10.2223/JPED.1785. View

11.

Williams M, Martin M . A longitudinal study of the effects on the oral mucosa of treatment for acute childhood leukaemia. Int J Paediatr Dent. 1992; 2(2):73-9. DOI: 10.1111/j.1365-263x.1992.tb00013.x. View

12.

Mendonca R, Araujo M, Levy C, Morari J, Silva R, Yunes J . Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia. Support Care Cancer. 2011; 20(5):1101-7. DOI: 10.1007/s00520-011-1190-0. View

13.

Sepet E, Aytepe Z, Ozerkan A, Yalman N, Guven Y, Anak S . Acute lymphoblastic leukemia: dental health of children in maintenance therapy. J Clin Pediatr Dent. 1998; 22(3):257-60. View

14.

Epstein J, Tsang A, Warkentin D, Ship J . The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94(1):39-44. DOI: 10.1067/moe.2002.126018. View

15.

Subramaniam P, Babu K, Nagarathna J . Oral manifestations in acute lymphoblastic leukemic children under chemotherapy. J Clin Pediatr Dent. 2008; 32(4):319-24. DOI: 10.17796/jcpd.32.4.0p1462t621w20477. View