Immunological Challenges and Therapies in Xenotransplantation

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2014 Mar 12

PMID 24616201

Citations 9

Authors

Marta Vadori

Emanuele Cozzi

Affiliations

Soon will be listed here.

Abstract

Xenotransplantation, or the transplantation of cells, tissues, or organs between different species, was proposed a long time ago as a possible solution to the worldwide shortage of human organs and tissues for transplantation. In this setting, the pig is currently seen as the most likely candidate species. In the last decade, progress in this field has been remarkable and includes a better insight into the immunological mechanisms underlying the rejection process. Several immunological hurdles nonetheless remain, such as the strong antibody-mediated and innate or adaptive cellular immune responses linked to coagulation derangements, precluding indefinite xenograft survival. This article reviews our current understanding of the immunological mechanisms involved in xenograft rejection and the potential strategies that may enable xenotransplantation to become a clinical reality in the not-too-distant future.

Citing Articles

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