Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2014 Mar 11

PMID 24609836

Citations 18

Authors

Thiago Santos Ferreira

Manuella Lanzetti

Marina Valente Barroso

Carlos Romualdo Rueff-Barroso

Claudia Farias Benjamim

Lycia de Brito-Gitirana

Luis Cristovao Porto

Samuel Santos Valenca

Affiliations

Soon will be listed here.

Abstract

Our aim was to investigate the effects of four different statins on acute lung inflammation induced by cigarette smoke (CS). C57BL/6 male mice were divided into a control group (sham-smoked) and mice exposed to CS from 12 cigarettes/day for 5 days. Mice exposed to CS were grouped and treated with vehicle (i.p.), atorvastatin (10 mg/kg), pravastatin (10 mg/kg), rosuvastatin (5 mg/kg), or simvastatin (20 mg/kg). Treatment with statins differentially improved the pulmonary response when compared to the CS group. Atorvastatin and pravastatin demonstrated slightly effects on inflammation and oxidative stress. Rosuvastatin demonstrated the best anti-inflammatory effect, whereas simvastatin demonstrated the best antioxidant response.

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