Modulation of Gut Microbiota in the Management of Metabolic Disorders: the Prospects and Challenges

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2014 Mar 11

PMID 24608927

Citations 47

Authors

Omotayo O Erejuwa

Siti A Sulaiman

Mohd S Ab Wahab

Affiliations

Soon will be listed here.

Abstract

The gut microbiota plays a number of important roles including digestion, metabolism, extraction of nutrients, synthesis of vitamins, prevention against pathogen colonization, and modulation of the immune system. Alterations or changes in composition and biodiversity of the gut microbiota have been associated with many gastrointestinal tract (GIT) disorders such as inflammatory bowel disease and colon cancer. Recent evidence suggests that altered composition and diversity of gut microbiota may play a role in the increased prevalence of metabolic diseases. This review article has two main objectives. First, it underscores approaches (such as probiotics, prebiotics, antimicrobial agents, bariatric surgery, and weight loss strategies) and their prospects in modulating the gut microbiota in the management of metabolic diseases. Second, it highlights some of the current challenges and discusses areas of future research as it relates to the gut microbiota and metabolic diseases. The prospect of modulating the gut microbiota seems promising. However, considering that research investigating the role of gut microbiota in metabolic diseases is still in its infancy, more rigorous and well-designed in vitro, animal and clinical studies are needed.

Citing Articles

An Analysis of the Digestive and Reproductive Tract Microbiota in Infertile Women with Obesity.

Bellver J, Gonzalez-Monfort M, Gonzalez S, Toson B, Labarta E, Castillon G Int J Mol Sci. 2024; 25(23.

PMID: 39684312 PMC: 11641297. DOI: 10.3390/ijms252312600.

Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice.

Guo D, Deng Y, Yang Q, Li M, Wang X, Wan X Gut Microbes. 2024; 16(1):2420771.

PMID: 39488738 PMC: 11540072. DOI: 10.1080/19490976.2024.2420771.

Association of Firmicutes/Bacteroidetes Ratio with Body Mass Index in Korean Type 2 Diabetes Mellitus Patients.

Ahmed K, Choi H, Cho S, Yim J Metabolites. 2024; 14(10).

PMID: 39452900 PMC: 11509432. DOI: 10.3390/metabo14100518.

Food Additives' Impact on Gut Microbiota and Metabolic Syndrome: A Systematic Review.

Singh S, Olayinka O, Fr J, Nisar M, Kotha R, Saad-Omer S Cureus. 2024; 16(8):e66822.

PMID: 39280570 PMC: 11398613. DOI: 10.7759/cureus.66822.

The gut microbiota improves reproductive dysfunction in obese mice by suppressing the NLRP3/ASC/caspase-1 axis.

Huang H, Zhou T, He F, Wen B, Yang Y, Zhong W Future Microbiol. 2024; 19(16):1389-1405.

PMID: 39225491 PMC: 11552480. DOI: 10.1080/17460913.2024.2386867.

References

Matheus A, Tannus L, Cobas R, Palma C, Negrato C, Gomes M . Impact of diabetes on cardiovascular disease: an update. Int J Hypertens. 2013; 2013:653789. PMC: 3603160. DOI: 10.1155/2013/653789. View

OSullivan O, Coakley M, Lakshminarayanan B, Conde S, Claesson M, Cusack S . Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy. J Antimicrob Chemother. 2012; 68(1):214-21. DOI: 10.1093/jac/dks348. View

Duncan S, Lobley G, Holtrop G, Ince J, Johnstone A, Louis P . Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond). 2008; 32(11):1720-4. DOI: 10.1038/ijo.2008.155. View

Stsepetova J, Sepp E, Kolk H, Loivukene K, Songisepp E, Mikelsaar M . Diversity and metabolic impact of intestinal Lactobacillus species in healthy adults and the elderly. Br J Nutr. 2011; 105(8):1235-44. DOI: 10.1017/S0007114510004770. View

Mazloom Z, Yousefinejad A, Dabbaghmanesh M . Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: a clinical trial. Iran J Med Sci. 2013; 38(1):38-43. PMC: 3642943. View

Sakai T, Taki T, Nakamoto A, Shuto E, Tsutsumi R, Toshimitsu T . Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet. J Nutr Sci Vitaminol (Tokyo). 2013; 59(2):144-7. DOI: 10.3177/jnsv.59.144. View

Erejuwa O, Sulaiman S, Ab Wahab M . Oligosaccharides might contribute to the antidiabetic effect of honey: a review of the literature. Molecules. 2011; 17(1):248-66. PMC: 6268503. DOI: 10.3390/molecules17010248. View

Sanz M, Polemis N, Morales V, Corzo N, Drakoularakou A, Gibson G . In vitro investigation into the potential prebiotic activity of honey oligosaccharides. J Agric Food Chem. 2005; 53(8):2914-21. DOI: 10.1021/jf0500684. View

Sousa T, Paterson R, Moore V, Carlsson A, Abrahamsson B, Basit A . The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm. 2008; 363(1-2):1-25. DOI: 10.1016/j.ijpharm.2008.07.009. View

10.

COATES M . Gnotobiotic animals in research: their uses and limitations. Lab Anim. 1975; 9(4):275-82. DOI: 10.1258/002367775780957296. View

11.

Stachowicz N, Kiersztan A . [The role of gut microbiota in the pathogenesis of obesity and diabetes]. Postepy Hig Med Dosw (Online). 2013; 67:288-303. DOI: 10.5604/17322693.1044746. View

12.

Hernandez E, Bargiela R, Suarez Diez M, Friedrichs A, Perez-Cobas A, Gosalbes M . Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity. Gut Microbes. 2013; 4(4):306-15. PMC: 3744515. DOI: 10.4161/gmic.25321. View

13.

Nadal I, Santacruz A, Marcos A, Warnberg J, Garagorri J, Garagorri M . Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents. Int J Obes (Lond). 2008; 33(7):758-67. DOI: 10.1038/ijo.2008.260. View

14.

Ejtahed H, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V . Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 2011; 28(5):539-43. DOI: 10.1016/j.nut.2011.08.013. View

15.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

16.

Lappi J, Salojarvi J, Kolehmainen M, Mykkanen H, Poutanen K, de Vos W . Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome. J Nutr. 2013; 143(5):648-55. DOI: 10.3945/jn.112.172668. View

17.

Zhang Y, Wang L, Zhang J, Li Y, He Q, Li H . Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Eur J Nutr. 2013; 53(1):221-32. DOI: 10.1007/s00394-013-0519-5. View

18.

Carvalho F, Aitken J, Vijay-Kumar M, Gewirtz A . Toll-like receptor-gut microbiota interactions: perturb at your own risk!. Annu Rev Physiol. 2011; 74:177-98. DOI: 10.1146/annurev-physiol-020911-153330. View

19.

Backhed F, Manchester J, Semenkovich C, Gordon J . Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007; 104(3):979-84. PMC: 1764762. DOI: 10.1073/pnas.0605374104. View

20.

Sweeney T, Morton J . The human gut microbiome: a review of the effect of obesity and surgically induced weight loss. JAMA Surg. 2013; 148(6):563-9. PMC: 4392891. DOI: 10.1001/jamasurg.2013.5. View