Effect of Cinnamon Water Extract on Monocyte-to-macrophage Differentiation and Scavenger Receptor Activity

Overview

Journal BMC Complement Altern Med

Publisher Biomed Central

Specialty Rehabilitation Medicine

Date 2014 Mar 8

PMID 24602512

Citations 7

Authors

Hee Kang

Sung-Hyun Park

Jeong-Moon Yun

Tae-Gyu Nam

Young-Eun Kim

Dae-Ok Kim

Youn Jung Kim

Affiliations

Soon will be listed here.

Abstract

Background: Water soluble cinnamon extract has been shown to increase insulin sensitivity and modulate macrophage activation, a desirable trait for the management of obesity or atherosclerosis. Our present study investigated whether cinnamon water extract (CWE) may influence the differentiation of monocytes into macrophages and the activity of macrophage scavenger receptors, commonly observed in atherosclerotic lesions.

Methods: We investigated the effect of CWE on the expression of various surface markers and the uptake of acetylated low density lipoprotein (LDL) in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 cells. The protein levels of PMA or macrophage-colony stimulating factor (M-CSF)-stimulated type 1 macrophage scavenger receptor (SRA) were analyzed. Finally, the role of extracellar signal-related kinase (ERK) 1/2 in SRA synthesis and the effect of CWE on PMA-stimulated ERK1/2 were determined.

Results: CWE inhibited the differentiation of monocyte by decreasing the expression of CD11b, CD36 and SRA and the uptake of acetyl LDL. CWE suppressed the upregulation of SRA by M-CSF and modulated ERK1/2 activity, which was required for PMA-induced SRA synthesis.

Conclusions: Our results demonstrate that CWE was able to interfere with monocyte differentiation and macrophage scavenger activity, indicating its potential in preventing the development of atherosclerotic lesions.

Citing Articles

Nrf2 Pathway and Oxidative Stress as a Common Target for Treatment of Diabetes and Its Comorbidities.

Yi M, Cruz Cisneros L, Cho E, Alexander M, Kimelman F, Swentek L Int J Mol Sci. 2024; 25(2).

PMID: 38255895 PMC: 10815857. DOI: 10.3390/ijms25020821.

Aqueous Extract of Cinnamon ( spp.): Role in Cancer and Inflammation.

Khedkar S, Khan M Evid Based Complement Alternat Med. 2023; 2023:5467342.

PMID: 37215636 PMC: 10195174. DOI: 10.1155/2023/5467342.

Natural drugs targeting inflammation pathways can be used to treat atherosclerosis.

Song X, Wang X, Wang D, Zheng Z, Li J, Li Y Front Pharmacol. 2022; 13:998944.

PMID: 36386165 PMC: 9663817. DOI: 10.3389/fphar.2022.998944.

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies.

Arozal W, Louisa M, Soetikno V Front Cardiovasc Med. 2020; 7:82.

PMID: 32435657 PMC: 7218133. DOI: 10.3389/fcvm.2020.00082.

Cinnamon and its Metabolite Protect the Nigrostriatum in a Mouse Model of Parkinson's Disease Via Astrocytic GDNF.

Patel D, Jana A, Roy A, Pahan K J Neuroimmune Pharmacol. 2019; 14(3):503-518.

PMID: 31119595 PMC: 6708487. DOI: 10.1007/s11481-019-09855-0.

References

Zhang X, Mosser D . Macrophage activation by endogenous danger signals. J Pathol. 2007; 214(2):161-78. PMC: 2724989. DOI: 10.1002/path.2284. View

Prieur X, Roszer T, Ricote M . Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome. Biochim Biophys Acta. 2009; 1801(3):327-37. DOI: 10.1016/j.bbalip.2009.09.017. View

Peng X, Cheng K, Ma J, Chen B, Ho C, Lo C . Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. J Agric Food Chem. 2008; 56(6):1907-11. DOI: 10.1021/jf073065v. View

de Villiers W, Fraser I, Hughes D, Doyle A, Gordon S . Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function. J Exp Med. 1994; 180(2):705-9. PMC: 2191609. DOI: 10.1084/jem.180.2.705. View

Traore K, Trush M, George Jr M, Spannhake E, Anderson W, Asseffa A . Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent. Leuk Res. 2005; 29(8):863-79. DOI: 10.1016/j.leukres.2004.12.011. View

Kunjathoor V, Febbraio M, Podrez E, Moore K, Andersson L, Koehn S . Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002; 277(51):49982-8. DOI: 10.1074/jbc.M209649200. View

Matta Reddy A, Seo J, Ryu S, Kim Y, Kim Y, Min K . Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Med. 2004; 70(9):823-7. DOI: 10.1055/s-2004-827230. View

Anderson R, Broadhurst C, Polansky M, Schmidt W, Khan A, Flanagan V . Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004; 52(1):65-70. DOI: 10.1021/jf034916b. View

Moore K, Rosen E, Fitzgerald M, RANDOW F, Andersson L, Altshuler D . The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001; 7(1):41-7. DOI: 10.1038/83328. View

10.

Rambaldi A, Young D, Griffin J . Expression of the M-CSF (CSF-1) gene by human monocytes. Blood. 1987; 69(5):1409-13. View

11.

Clinton S, Underwood R, Hayes L, Sherman M, Kufe D, Libby P . Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol. 1992; 140(2):301-16. PMC: 1886415. View

12.

Prudovsky I, Popov K, Akimov S, Serov S, Zelenin A, Meinhardt G . Antisense CD11b integrin inhibits the development of a differentiated monocyte/macrophage phenotype in human leukemia cells. Eur J Cell Biol. 2002; 81(1):36-42. DOI: 10.1078/0171-9335-00219. View

13.

Moore K, Freeman M . Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol. 2006; 26(8):1702-11. DOI: 10.1161/01.ATV.0000229218.97976.43. View

14.

Rajavashisth T, Andalibi A, Territo M, Berliner J, Navab M, Fogelman A . Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins. Nature. 1990; 344(6263):254-7. DOI: 10.1038/344254a0. View

15.

Schwende H, Fitzke E, Ambs P, Dieter P . Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3. J Leukoc Biol. 1996; 59(4):555-61. View

16.

Ueda Y, Hirai S, Osada S, Suzuki A, Mizuno K, Ohno S . Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem. 1996; 271(38):23512-9. DOI: 10.1074/jbc.271.38.23512. View

17.

Lundberg A, Hansson G . Innate immune signals in atherosclerosis. Clin Immunol. 2009; 134(1):5-24. DOI: 10.1016/j.clim.2009.07.016. View

18.

Nikolic D, Calderon L, Du L, Post S . SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation. BMC Immunol. 2011; 12:37. PMC: 3141791. DOI: 10.1186/1471-2172-12-37. View

19.

Stephen S, Freestone K, Dunn S, Twigg M, Homer-Vanniasinkam S, Walker J . Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease. Int J Hypertens. 2010; 2010:646929. PMC: 2958427. DOI: 10.4061/2010/646929. View

20.

Zhuang M, Jiang H, Suzuki Y, Li X, Xiao P, Tanaka T . Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection. Antiviral Res. 2009; 82(1):73-81. PMC: 7114128. DOI: 10.1016/j.antiviral.2009.02.001. View