Stro-1-positive BMSCs Predict Postoperative Periprosthetic Bone Mineral Density Outcomes in Uncemented Total Hip Arthroplasty Patients

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2014 Mar 5

PMID 24589638

Citations 2

Authors

Yi Shen

Xiaomiao Li

Yurun Ding

Weiping Ren

Weili Wang

Affiliations

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Abstract

Background: Bone marrow cell profiles are variable after total hip arthroplasty (THA), including variable levels of Stro-1+ and bone morphogenetic protein receptor (BMPRs)+ cells. We investigated the impact of bone marrow cell profiles on changes in periprosthetic bone mineral density (BMD) in uncemented THA patients.

Material And Methods: Bone marrow aspirates were collected from the metaphyseal region of discarded femoral heads from 24 consecutive THA patients (12 men and 12 women; mean age 66.7 ± 11.0 years; range 52-87 years) treated from March 2009 to March 2011 at a single facility. Perioperative proportions of Stro-1+ and BMPR+ cells in femoral heads were assessed by flow cytometry. Follow-up examined the proximal femur Gruen zones R1 and R7 at 1 week and at 3, 6, and 12 months after THA, using dual-energy X-ray absorptiometry. Associations between BMD loss and age, gender, BMPRs+, and Stro-1+ were analyzed.

Results: At 3 months, R1 and R7 BMD decreased by 4.4% and 6.4%, respectively (P<0.05). At 12 months, the overall BMD decreases in R1 and R7 were 10.2% and 1%, respectively (P<0.05). Higher Stro-1+ cells proportion predicted R7 BMD increases at all time points (P<0.05) and R1 BMD increases at 6 and 12 months (P<0.05). BMPR1a+ proportion was associated with BMD increases at 6 months in the R1 region. BMPR2+ was not significantly associated with BMD (P>0.05).

Conclusions: Elevated Stro-1+ bone marrow cell profile may be a useful prognostic indicator for uncemented THA patients.

Citing Articles

Stem length in primary cementless total hip arthroplasty: Does it make a difference in bone remodeling?.

Samy A, El-Tantawy A Eur J Orthop Surg Traumatol. 2019; 29(6):1235-1242.

PMID: 30989339 DOI: 10.1007/s00590-019-02437-z.

E7 peptide-functionalized Ti6Al4V alloy for BMSC enrichment in bone tissue engineering.

Man Z, Li T, Zhang L, Yuan L, Wu C, Li P Am J Transl Res. 2018; 10(8):2480-2490.

PMID: 30210686 PMC: 6129526.

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