Human Mulipotential Mesenchymal/stromal Stem Cells Are Derived from a Discrete Subpopulation of STRO-1bright/CD34 /CD45(-)/glycophorin-A-bone Marrow Cells

Overview

Journal Haematologica

Specialty Hematology

Date 2007 Dec 7

PMID 18055998

Citations 23

Authors

Andrew C W Zannettino

Sharon Paton

Angela Kortesidis

Fiona Khor

Silviu Itescu

Stan Gronthos

Affiliations

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Abstract

Magnetic and flow cytometry-based methods were used to characterize clonogenic stromal cells in human bone marrow. STRO-1(bright) stromal cells were found to lack expression of CD34, CD45 and glycophorin-A markers associated with hematopoietic progenitor cells. These studies support the view that these are two distinct stem cell compartments in adult bone marrow.

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