Characterization of Eosinophilic Esophagitis Murine Models Using Optical Coherence Tomography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2014 Feb 28

PMID 24575353

Citations 3

Authors

Aneesh Alex

Mario Noti

Elia D Tait Wojno

David Artis

Chao Zhou

Affiliations

Soon will be listed here.

Abstract

Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo. Structural changes in the esophagus of wild-type (Tslpr(+/+) ) and mutant (Tslpr(-/-) ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a label-free imaging tool devoid of tissue-processing artifacts to effectively characterize murine EoE-like disease models has been demonstrated.

Citing Articles

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