Does Aneuploidy Destabilize Karyotypes Automatically?

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2014 Feb 27

PMID 24569866

Citations 8

Authors

Peter H Duesberg

Affiliations

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Citing Articles

Is cancer progression caused by gradual or simultaneous acquisitions of new chromosomes?.

Bloomfield M, Duesberg P Mol Cytogenet. 2018; 11:4.

PMID: 29371887 PMC: 5769399. DOI: 10.1186/s13039-017-0350-4.

The wayward methyl group and the cascade to cancer.

Hoffman R Cell Cycle. 2017; 16(9):825-829.

PMID: 28318368 PMC: 5444351. DOI: 10.1080/15384101.2017.1304330.

Inherent variability of cancer-specific aneuploidy generates metastases.

Bloomfield M, Duesberg P Mol Cytogenet. 2016; 9:90.

PMID: 28018487 PMC: 5160004. DOI: 10.1186/s13039-016-0297-x.

Origin of Cancer: An Information, Energy, and Matter Disease.

Hanselmann R, Welter C Front Cell Dev Biol. 2016; 4:121.

PMID: 27909692 PMC: 5112236. DOI: 10.3389/fcell.2016.00121.

Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells.

Bloomfield M, Duesberg P Mol Cytogenet. 2015; 8:79.

PMID: 26500699 PMC: 4618876. DOI: 10.1186/s13039-015-0183-y.

References

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Reish O, Regev M, Kanesky A, Girafi S, Mashevich M . Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13. Cytogenet Genome Res. 2011; 133(2-4):184-9. DOI: 10.1159/000323504. View

Fabarius A, Hehlmann R, Duesberg P . Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy. Cancer Genet Cytogenet. 2003; 143(1):59-72. DOI: 10.1016/s0165-4608(03)00003-7. View

Duesberg P, Rausch C, Rasnick D, Hehlmann R . Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci U S A. 1998; 95(23):13692-7. PMC: 24881. DOI: 10.1073/pnas.95.23.13692. View

Camps J, Ponsa I, Ribas M, Prat E, Egozcue J, Peinado M . Comprehensive measurement of chromosomal instability in cancer cells: combination of fluorescence in situ hybridization and cytokinesis-block micronucleus assay. FASEB J. 2005; 19(7):828-30. DOI: 10.1096/fj.04-2276fje. View