The Proteasome and the Degradation of Oxidized Proteins: Part III-Redox Regulation of the Proteasomal System

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2014 Feb 25

PMID 24563857

Citations 78

Authors

Tobias Jung Annika Hohn

Tilman Grune

Affiliations

Soon will be listed here.

Abstract

Here, we review shortly the current knowledge on the regulation of the proteasomal system during and after oxidative stress. After addressing the components of the proteasomal system and the degradation of oxidatively damaged proteins in part I and II of this series, we address here which changes in activity undergo the proteasome and the ubiquitin-proteasomal system itself under oxidative conditions. While several components of the proteasomal system undergo direct oxidative modification, a number of redox-regulated events are modulating the proteasomal activity in a way it can address the major tasks in an oxidative stress situation: the removal of oxidized proteins and the adaptation of the cellular metabolism to the stress situation.

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