Imaging of Prostate Cancer: a Platform for 3D Co-registration of In-vivo MRI Ex-vivo MRI and Pathology

Overview

Journal Proc SPIE Int Soc Opt Eng

Date 2014 Feb 25

PMID 24563727

Citations 12

Authors

Clement Orczyk

Artem Mikheev

Andrew B Rosenkrantz

Jonathan Melamed

Samir S Taneja

Henry Rusinek

Affiliations

Soon will be listed here.

Abstract

Objectives: Multi-parametric MRI is emerging as a promising method for prostate cancer diagnosis. prognosis and treatment planning. However, the localization of in-vivo detected lesions and pathologic sites of cancer remains a significant challenge. To overcome this limitation we have developed and tested a system for co-registration of in-vivo MRI, ex-vivo MRI and histology.

Materials And Methods: Three men diagnosed with localized prostate cancer (ages 54-72, PSA levels 5.1-7.7 ng/ml) were prospectively enrolled in this study. All patients underwent 3T multi-parametric MRI that included T2W, DCE-MRI, and DWI prior to robotic-assisted prostatectomy. Ex-vivo multi-parametric MRI was performed on fresh prostate specimen. Excised prostates were then sliced at regular intervals and photographed both before and after fixation. Slices were perpendicular to the main axis of the posterior capsule, i.e., along the direction of the rectal wall. Guided by the location of the urethra, 2D digital images were assembled into 3D models. Cancer foci, extra-capsular extensions and zonal margins were delineated by the pathologist and included in 3D histology data. A locally-developed software was applied to register in-vivo, ex-vivo and histology using an over-determined set of anatomical landmarks placed in anterior fibro-muscular stroma, central. transition and peripheral zones. The mean root square distance across corresponding control points was used to assess co-registration error.

Results: Two specimens were pT3a and one pT2b (negative margin) at pathology. The software successfully fused in-vivo MRI. ex-vivo MRI fresh specimen and histology using appropriate (rigid and affine) transformation models with mean square error of 1.59 mm. Coregistration accuracy was confirmed by multi-modality viewing using operator-guided variable transparency.

Conclusion: The method enables successful co-registration of pre-operative MRI, ex-vivo MRI and pathology and it provides initial evidence of feasibility of MRI-guided surgical planning.

Citing Articles

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Liver-specific 3D sectioning molds for correlating in vivo CT and MRI with tumor histopathology in woodchucks (Marmota monax).

Mikhail A, Mauda-Havakuk M, Partanen A, Karanian J, Pritchard W, Wood B PLoS One. 2020; 15(3):e0230794.

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Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology.

Wildeboer R, Van Sloun R, Postema A, Mannaerts C, Gayet M, Beerlage H J Ultrasound. 2018; 21(3):197-207.

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Registration Accuracy of Patient-Specific, Three-Dimensional-Printed Prostate Molds for Correlating Pathology With Magnetic Resonance Imaging.

Priester A, Wu H, Khoshnoodi P, Schneider D, Zhang Z, Asvadi N IEEE Trans Biomed Eng. 2018; 66(1):14-22.

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Co-Registration of ex vivo Surgical Histopathology and in vivo T2 weighted MRI of the Prostate via multi-scale spectral embedding representation.

Li L, Pahwa S, Penzias G, Rusu M, Gollamudi J, Viswanath S Sci Rep. 2017; 7(1):8717.

PMID: 28821786 PMC: 5562695. DOI: 10.1038/s41598-017-08969-w.

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