» Articles » PMID: 24553878

Structural Brain Changes in Prenatal Methamphetamine-exposed Children

Overview
Journal Metab Brain Dis
Publisher Springer
Specialties Endocrinology
Neurology
Date 2014 Feb 21
PMID 24553878
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

The global use of methamphetamine (MA) has increased substantially in recent years, but the effect of MA on brain structure in prenatally exposed children is understudied. Here we aimed to investigate potential changes in brain volumes and cortical thickness of children with prenatal MA-exposure compared to unexposed controls. Eighteen 6-year old children with MA-exposure during pregnancy and 18 healthy controls matched for age, gender and socio-economic background underwent structural imaging. Brain volumes and cortical thickness were assessed using Freesurfer and compared using ANOVA. Left putamen volume was significantly increased, and reduced cortical thickness was observed in the left hemisphere of the inferior parietal, parsopercularis and precuneus areas of MA-exposed children compared to controls. Compared to control males, prenatal MA-exposed males had greater volumes in striatal and associated areas, whereas MA-exposed females predominantly had greater cortical thickness compared to control females. In utero exposure to MA results in changes in the striatum of the developing child. In addition, changes within the striatal, frontal, and parietal areas are in part gender dependent.

Citing Articles

METH exposure alters sperm DNA methylation in F0 mice and mPFC transcriptome in male F1 mice.

Li Z, Liu D, Wang G, Zheng Y, Chen L, Cheng Z Psychopharmacology (Berl). 2023; 241(5):897-911.

PMID: 38092953 DOI: 10.1007/s00213-023-06516-2.


Maternal use of methamphetamine alters cardiovascular function in the adult offspring.

Belcher A, Rorabaugh B Biochem Cell Biol. 2023; 101(3):198-203.

PMID: 36763967 PMC: 10563036. DOI: 10.1139/bcb-2022-0349.


Maternal use of methamphetamine induces sex-dependent changes in myocardial gene expression in adult offspring.

Dague A, Chavva H, Brazeau D, Denvir J, Rorabaugh B Physiol Rep. 2022; 10(22):e15509.

PMID: 36426716 PMC: 9693808. DOI: 10.14814/phy2.15509.


Methamphetamine Use During the First or Second Half of Pregnancy Worsens Cardiac Ischemic Injury in Adult Female Offspring.

Chavva H, Rorabaugh B Physiol Res. 2022; 71(4):501-508.

PMID: 35899942 PMC: 9616592.


Feasibility of FreeSurfer Processing for T1-Weighted Brain Images of 5-Year-Olds: Semiautomated Protocol of FinnBrain Neuroimaging Lab.

Pulli E, Silver E, Kumpulainen V, Copeland A, Merisaari H, Saunavaara J Front Neurosci. 2022; 16:874062.

PMID: 35585923 PMC: 9108497. DOI: 10.3389/fnins.2022.874062.


References
1.
Pluddemann A, Myers B, Parry C . Surge in treatment admissions related to methamphetamine use in Cape Town, South Africa: implications for public health. Drug Alcohol Rev. 2008; 27(2):185-9. DOI: 10.1080/09595230701829363. View

2.
Won L, Bubula N, McCoy H, Heller A . Methamphetamine concentrations in fetal and maternal brain following prenatal exposure. Neurotoxicol Teratol. 2001; 23(4):349-54. DOI: 10.1016/s0892-0362(01)00151-9. View

3.
Sowell E, Leow A, Bookheimer S, Smith L, OConnor M, Kan E . Differentiating prenatal exposure to methamphetamine and alcohol versus alcohol and not methamphetamine using tensor-based brain morphometry and discriminant analysis. J Neurosci. 2010; 30(11):3876-85. PMC: 2847574. DOI: 10.1523/JNEUROSCI.4967-09.2010. View

4.
Sowell E, Peterson B, Kan E, Woods R, Yoshii J, Bansal R . Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age. Cereb Cortex. 2006; 17(7):1550-60. PMC: 2329809. DOI: 10.1093/cercor/bhl066. View

5.
Heller A, Bubula N, Freeney A, Won L . Elevation of fetal dopamine following exposure to methamphetamine in utero. Brain Res Dev Brain Res. 2001; 130(1):139-42. DOI: 10.1016/s0165-3806(01)00222-x. View