Classic and Current Opinion in Embryonic Organ Transplantation

Overview

Journal Curr Opin Organ Transplant

Specialty General Surgery

Date 2014 Feb 19

PMID 24535425

Citations 3

Authors

Marc R Hammerman

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Here, we review the rationale for the use of organs from embryonic donors, antecedent investigations and recent work from our own laboratory, exploring the utility for transplantation of embryonic kidney and pancreas as an organ replacement therapy.

Recent Findings: Ultrastructurally precise kidneys differentiate in situ in rats following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host. Engraftment of pig renal primordia requires host immune suppression. However, beta cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans occurs in animals previously transplanted with E28 pig pancreatic primordia.

Summary: Organ primordia engraft, attract a host vasculature and differentiate following transplantation to ectopic sites. Attempts have been made to exploit these characteristics to achieve clinically relevant endpoints for end-stage renal disease and diabetes mellitus using animal models. We and others have focused on use of the embryonic pig as a donor.

Citing Articles

Sex-bias metabolism of fetal organs, and their relationship to the regulation of fetal brain-placental axis.

Poudel S, Behura S Metabolomics. 2024; 20(6):126.

PMID: 39495316 DOI: 10.1007/s11306-024-02189-w.

Current Bioengineering and Regenerative Strategies for the Generation of Kidney Grafts on Demand.

Garcia-Dominguez X, Vicente J, Vera-Donoso C, Marco-Jimenez F Curr Urol Rep. 2017; 18(1):2.

PMID: 28092070 DOI: 10.1007/s11934-017-0650-6.

Underpinnings of cellular organ replacement therapies.

Hammerman M Curr Opin Organ Transplant. 2014; 19(2):131-2.

PMID: 24553503 PMC: 4094313. DOI: 10.1097/MOT.0000000000000056.

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