Transplantation of Renal Primordia: Renal Organogenesis

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2007 Aug 2

PMID 17668242

Citations 8

Authors

Marc R Hammerman

Affiliations

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Abstract

Dialysis and allotransplantation of human kidneys represent effective therapies to replace kidney function, but the former replaces only a small component of renal function, and the latter is limited by lack of organ availability. Xenotransplantation of whole kidneys from nonprimate donors is complicated by humoral and severe cellular rejection. The use of individual cells or groups of cells to repair damaged tissue (cellular therapies) offers an alternative for renal tissue replacement. However, recapitulation of complex functions such glomerular filtration and reabsorption and secretion of solutes that are dependent on a three-dimensionally integrated kidney structure are beyond the scope of most cellular replacement therapies. The use of nonvascularized embryonic renal primordia for transplantation circumvents humoral rejection of xenogeneic tissue and ameliorates cellular rejection. Renal primordia are preprogrammed to attract a vasculature and differentiate into a kidney and in this manner undergo organogenesis after transplantation into the mesentery of hosts. Here we review a decade's progress in renal organogenesis.

Citing Articles

Sildenafil Citrate Enhances Renal Organogenesis Following Metanephroi Allotransplantation into Non-Immunosuppressed Hosts.

Garcia-Dominguez X, Vera-Donoso C, Lopez-Moncholi E, Moreno-Manzano V, Vicente J, Marco-Jimenez F J Clin Med. 2022; 11(11).

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Current Bioengineering and Regenerative Strategies for the Generation of Kidney Grafts on Demand.

Garcia-Dominguez X, Vicente J, Vera-Donoso C, Marco-Jimenez F Curr Urol Rep. 2017; 18(1):2.

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Current strategies and challenges in engineering a bioartificial kidney.

Kim S, Fissell W, Humes D, Roy S Front Biosci (Elite Ed). 2015; 7(2):215-28.

PMID: 25553375 PMC: 4383659. DOI: 10.2741/E729.

Classic and current opinion in embryonic organ transplantation.

Hammerman M Curr Opin Organ Transplant. 2014; 19(2):133-9.

PMID: 24535425 PMC: 4094307. DOI: 10.1097/MOT.0000000000000054.

Engineering kidneys from simple cell suspensions: an exercise in self-organization.

Davies J, Chang C Pediatr Nephrol. 2013; 29(4):519-24.

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References

Foglia R, DiPreta J, Statter M, Donahoe P . Fetal allograft survival in immunocompetent recipients is age dependent and organ specific. Ann Surg. 1986; 204(4):402-10. PMC: 1251308. DOI: 10.1097/00000658-198610000-00008. View

Rogers S, Liapis H, Hammerman M . Transplantation of metanephroi across the major histocompatibility complex in rats. Am J Physiol Regul Integr Comp Physiol. 2000; 280(1):R132-6. DOI: 10.1152/ajpregu.2001.280.1.R132. View

Hammerman M . Regulation of cell survival during renal development. Pediatr Nephrol. 1998; 12(7):596-602. DOI: 10.1007/s004670050513. View

Velasco A, Hegre O . Decreased immunogenicity of fetal kidneys: the role of passenger leukocytes. J Pediatr Surg. 1989; 24(1):59-63; discussion 63. DOI: 10.1016/s0022-3468(89)80303-3. View

Dekel B, Marcus H, Herzel B, Bocher W, Passwell J, Reisner Y . In vivo modulation of the allogeneic immune response by human fetal kidneys: the role of cytokines, chemokines, and cytolytic effector molecules. Transplantation. 2000; 69(7):1470-8. DOI: 10.1097/00007890-200004150-00044. View

Statter M, Fahrner K, Barksdale Jr E, Parks D, Flavell R, Donahoe P . Correlation of fetal kidney and testis congenic graft survival with reduced major histocompatibility complex burden. Transplantation. 1989; 47(4):651-60. DOI: 10.1097/00007890-198904000-00017. View

Dekel B, Burakova T, Arditti F, Reich-Zeliger S, Milstein O, Aviel-Ronen S . Human and porcine early kidney precursors as a new source for transplantation. Nat Med. 2002; 9(1):53-60. DOI: 10.1038/nm812. View

Hammerman M . Transplantation of renal precursor cells: a new therapeutic approach. Pediatr Nephrol. 2000; 14(6):513-7. DOI: 10.1007/s004670050805. View

Danovitch G, Cohen D, Weir M, Stock P, Bennett W, Christensen L . Current status of kidney and pancreas transplantation in the United States, 1994-2003. Am J Transplant. 2005; 5(4 Pt 2):904-15. DOI: 10.1111/j.1600-6135.2005.00835.x. View

10.

Marshall D, Clancy M, Bottomley M, Symonds K, Brenchley P, Bravery C . Transplantation of metanephroi to sites within the abdominal cavity. Transplant Proc. 2005; 37(1):194-7. DOI: 10.1016/j.transproceed.2004.12.283. View

11.

Rogers S, Hammerman M . Transplantation of metanephroi after preservation in vitro. Am J Physiol Regul Integr Comp Physiol. 2001; 281(2):R661-5. DOI: 10.1152/ajpregu.2001.281.2.R661. View

12.

Yokoo T, Ohashi T, Shen J, Sakurai K, Miyazaki Y, Utsunomiya Y . Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues. Proc Natl Acad Sci U S A. 2005; 102(9):3296-300. PMC: 552897. DOI: 10.1073/pnas.0406878102. View

13.

Sorenson C, Rogers S, Korsmeyer S, Hammerman M . Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol. 1995; 268(1 Pt 2):F73-81. DOI: 10.1152/ajprenal.1995.268.1.F73. View

14.

Dekel B, Burakova T, Marcus H, Oren R, Laufer J, Reisner Y . Engraftment of human kidney tissue in rat radiation chimera: II. Human fetal kidneys display reduced immunogenicity to adoptively transferred human peripheral blood mononuclear cells and exhibit rapid growth and development. Transplantation. 1998; 64(11):1550-8. DOI: 10.1097/00007890-199712150-00008. View

15.

Woolf A, Loughna S . Origin of glomerular capillaries: is the verdict in?. Exp Nephrol. 1998; 6(1):17-21. DOI: 10.1159/000020500. View

16.

Rogers S, Droege D, Dusso A, Hammerman M . Incubation of metanephroi with vitamin d(3) increases numbers of glomeruli. Organogenesis. 2009; 1(2):52-4. PMC: 2633986. DOI: 10.4161/org.1.2.1292. View

17.

Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M . Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med. 2004; 11(1):32-4. DOI: 10.1038/nm1172. View

18.

Rogers S, Liapis H, Hammerman M . Normalization of glucose post-transplantation of pig pancreatic anlagen into non-immunosuppressed diabetic rats depends on obtaining anlagen prior to embryonic day 35. Transpl Immunol. 2005; 14(2):67-75. DOI: 10.1016/j.trim.2005.02.004. View

19.

Marshall D, Dilworth M, Clancy M, Bravery C, Ashton N . Increasing renal mass improves survival in anephric rats following metanephros transplantation. Exp Physiol. 2006; 92(1):263-71. DOI: 10.1113/expphysiol.2006.036319. View

20.

Armstrong S, Campbell G, Campbell J, Little M . Establishment of metanephros transplantation in mice highlights contributions by both nephrectomy and pregnancy to developmental progression. Nephron Exp Nephrol. 2005; 101(4):e155-64. DOI: 10.1159/000087939. View