Is Oxidative Stress Related to Childhood Urolithiasis?

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2014 Feb 15

PMID 24526098

Citations 7

Authors

Nilufer Goknar

Faruk Oktem

Engin Ari

Aysegul Dogan Demir

Emel Torun

Affiliations

Soon will be listed here.

Abstract

Background: Urolithiasis is a common condition in pediatric populations in Turkey. The role of oxidative stress in renal stone formation in pediatric patients has not been reported to date. The aim of this study was to assess oxidative stress in childhood urolithiasis.

Methods: Seventy-four children diagnosed with urolithiasis and 72 healthy control subjects were enrolled in the study. Kidney stone formers were evaluated by analysis of metabolic conditions related to urolithiasis, such as hypercalciuria, hyperoxaluria, hypocitraturia and hyperuricosuria. Urine total antioxidant status (TAS), and total oxidant status (TOS) were measured, and oxidative stress index (OSI) was calculated as an indicator of the degree of oxidative stress.

Results: Among the stone formers, metabolic analyses revealed that 30 % had hypercalciuria, 45 % had hypocitraturia, 6 % had hyperoxaluria and 40 % had hyperuricosuria. Elevated levels of the renal tubular damage marker urinary N-acetyl- beta-D-glucosaminidase (NAG) was elevated in 25 % of the patient group, but microalbuminuria was not detected. Total oxidant status and total antioxidant status were significantly higher in stone formers than in the controls (p = 0.023 and 0.004, respectively). In addition, urinary NAG was significantly correlated with TOS (r = 0.427, p = 0.019).

Conclusions: The results of this study show that oxidative stress may play an important role in the pathogenesis of pediatric stone formers.

Citing Articles

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The Molecular Aspect of Nephrolithiasis Development.

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Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis.

Sonmez M, Kozanhan B, Deniz C, Iyisoy M, Kilinc M, Ecer G Investig Clin Urol. 2019; 60(4):258-266.

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The comparison of oxidative stress effect in classic and tubeless percutaneous nephrolithotomy.

Bryniarski P, Kasperczyk S, Rajwa P, Stelmach P, Cisowska-Babraj M, Paradysz A Int Urol Nephrol. 2018; 50(12):2145-2152.

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