NADPH Oxidase As a Therapeutic Target for Oxalate Induced Injury in Kidneys

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2013 Jul 11

PMID 23840917

Citations 41

Authors

Sunil Joshi

Ammon B Peck

Saeed R Khan

Affiliations

Soon will be listed here.

Abstract

A major role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes is to catalyze the production of superoxides and other reactive oxygen species (ROS). These ROS, in turn, play a key role as messengers in cell signal transduction and cell cycling, but when they are produced in excess they can lead to oxidative stress (OS). Oxidative stress in the kidneys is now considered a major cause of renal injury and inflammation, giving rise to a variety of pathological disorders. In this review, we discuss the putative role of oxalate in producing oxidative stress via the production of reactive oxygen species by isoforms of NADPH oxidases expressed in different cellular locations of the kidneys. Most renal cells produce ROS, and recent data indicate a direct correlation between upregulated gene expressions of NADPH oxidase, ROS, and inflammation. Renal tissue expression of multiple NADPH oxidase isoforms most likely will impact the future use of different antioxidants and NADPH oxidase inhibitors to minimize OS and renal tissue injury in hyperoxaluria-induced kidney stone disease.

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References

Belostotsky R, Seboun E, Idelson G, Milliner D, Becker-Cohen R, Rinat C . Mutations in DHDPSL are responsible for primary hyperoxaluria type III. Am J Hum Genet. 2010; 87(3):392-9. PMC: 2933339. DOI: 10.1016/j.ajhg.2010.07.023. View

Keaney Jr J, Xu A, Cunningham D, Jackson T, Frei B, Vita J . Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. J Clin Invest. 1995; 95(6):2520-9. PMC: 295934. DOI: 10.1172/JCI117953. View

Sun Y, Asnicar M, Smith R . Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology. 2007; 86(3):215-28. DOI: 10.1159/000109094. View

Cayatte A, Rupin A, Maitland K, Sansilvestri-Morel P, Boussard M, Wierzbicki M . S17834, a new inhibitor of cell adhesion and atherosclerosis that targets nadph oxidase. Arterioscler Thromb Vasc Biol. 2001; 21(10):1577-84. DOI: 10.1161/hq1001.096723. View

t Hart B, Simons J, Bakker N, Labadie R . Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin. Free Radic Biol Med. 1990; 9(2):127-31. DOI: 10.1016/0891-5849(90)90115-y. View

Szabo C, Ischiropoulos H, Radi R . Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov. 2007; 6(8):662-80. DOI: 10.1038/nrd2222. View

Holmes R, Kennedy M . Estimation of the oxalate content of foods and daily oxalate intake. Kidney Int. 2000; 57(4):1662-7. DOI: 10.1046/j.1523-1755.2000.00010.x. View

Marengo S, Romani A . Oxalate in renal stone disease: the terminal metabolite that just won't go away. Nat Clin Pract Nephrol. 2008; 4(7):368-77. DOI: 10.1038/ncpneph0845. View

McCaffrey R, Schwartz J, Lindemann S, Moreland J, Buchan B, Jones B . Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol. 2010; 88(4):791-805. PMC: 2974429. DOI: 10.1189/jlb.1209811. View

10.

Hoppe B, Beck B, Milliner D . The primary hyperoxalurias. Kidney Int. 2009; 75(12):1264-1271. PMC: 4577278. DOI: 10.1038/ki.2009.32. View

11.

Bhandari A, Koul S, Sekhon A, Pramanik S, Chaturvedi L, Huang M . Effects of oxalate on HK-2 cells, a line of proximal tubular epithelial cells from normal human kidney. J Urol. 2002; 168(1):253-9. View

12.

Stolk J, Hiltermann T, Dijkman J, Verhoeven A . Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol. 1994; 11(1):95-102. DOI: 10.1165/ajrcmb.11.1.8018341. View

13.

Hou Y, Janczuk A, Wang P . Current trends in the development of nitric oxide donors. Curr Pharm Des. 1999; 5(6):417-41. View

14.

Li N, Yi F, Spurrier J, Bobrowitz C, Zou A . Production of superoxide through NADH oxidase in thick ascending limb of Henle's loop in rat kidney. Am J Physiol Renal Physiol. 2002; 282(6):F1111-9. DOI: 10.1152/ajprenal.00218.2001. View

15.

Kawahara T, Kuwano Y, Teshima-Kondo S, Takeya R, Sumimoto H, Kishi K . Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. J Immunol. 2004; 172(5):3051-8. DOI: 10.4049/jimmunol.172.5.3051. View

16.

ODonnell V, Smith G, Jones O . Involvement of phenyl radicals in iodonium inhibition of flavoenzymes. Mol Pharmacol. 1994; 46(4):778-85. View

17.

Kitiyakara C, Chabrashvili T, Chen Y, Blau J, Karber A, Aslam S . Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol. 2003; 14(11):2775-82. DOI: 10.1097/01.asn.0000092145.90389.65. View

18.

Anderson R . Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant-activated superoxide generation and autooxidation. J Infect Dis. 1989; 159(5):966-73. DOI: 10.1093/infdis/159.5.966. View

19.

Klebanoff S . Myeloperoxidase: friend and foe. J Leukoc Biol. 2005; 77(5):598-625. DOI: 10.1189/jlb.1204697. View

20.

Laursen J, Somers M, Kurz S, McCann L, Warnholtz A, Freeman B . Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation. 2001; 103(9):1282-8. DOI: 10.1161/01.cir.103.9.1282. View