Cytokine Candidate Genes Predict the Development of Secondary Lymphedema Following Breast Cancer Surgery

Overview

Journal Lymphat Res Biol

Specialty Allergy & Immunology

Date 2014 Feb 8

PMID 24502445

Citations 31

Authors

Geraldine Leung

Christina Baggott

Claudia West

Charles Elboim

Steven M Paul

Bruce A Cooper

Gary Abrams

Anand Dhruva

Brian L Schmidt

Kord Kober

John D Merriman

Heather Leutwyler

John Neuhaus

Dale Langford

Betty J Smoot

Bradley E Aouizerat

Christine Miaskowski

Affiliations

Soon will be listed here.

Abstract

Background: Lymphedema (LE) is a frequent complication following breast cancer treatment. While progress is being made in the identification of phenotypic risk factors for the development of LE, little information is available on the molecular characterization of LE. The purpose of this study was to determine if variations in pro- and anti-inflammatory cytokine genes were associated with LE following breast cancer treatment.

Methods And Results: Breast cancer patients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n=155) and without LE (n=387) for the majority of the demographic and clinical characteristics. Patients with LE had a significantly higher body mass index, more advanced disease, and a higher number of lymph nodes removed. Genetic associations were identified for three genes (i.e., interleukin (IL4) 4 (rs2227284), IL 10 (rs1518111), and nuclear kappa factor beta 2 (NFKB2 (rs1056890)) associated with inflammatory responses.

Conclusions: These genetic associations suggest a role for a number of pro- and anti-inflammatory genes in the development of LE following breast cancer treatment.

Citing Articles

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