Screening and Design of Anti-diabetic Compounds Sourced from the Leaves of Neem (Azadirachta Indica)

Overview

Journal Bioinformation

Specialty Biology

Date 2014 Feb 6

PMID 24497731

Citations 10

Authors

Asma Jalil

Usman Ali Ashfaq

Samar Shahzadi

Ijaz Rasul

Shahid-Ur Rehman

Masaud Shah

Muhammad Rizwan Javed

Muhammad Shareef Masoud

Affiliations

Soon will be listed here.

Abstract

Diabetes Mellitus is affecting people of all age groups worldwide. Many synthetic medicines available for type 2 diabetes mellitus in the market. However, there is a strong requirement for the development of better anti-diabetes compounds sourced especially from natural sources like medicinal plants. The extracts from the leaves of neem (Azadirachta indica) is traditionally known to have anti-diabetes properties. Therefore, there is an increased interest to identify potential compounds identified from neem leaf extracts showing predicted binding property with the known diabetes mellitus type 2 protein enzyme target phosphoenol-pyruvate carboxykinase(PEPCK). The structure data for compounds found in the leaf extract of neem was screened against PEPCK using molecular docking simulation and screening techniques. Results show that the compound 3-Deacetyl-3-cinnamoyl-azadirachtin possesses best binding properties with PEPCK. This observation finds application for further consideration in in vitro and in vivo validation.

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