Antihyperglycemic Activity of Compounds Isolated from Indian Medicinal Plants

Overview

Journal Indian J Exp Biol

Specialty Biology

Date 2010 Nov 5

PMID 21046984

Citations 8

Authors

Akanksha

Arvind K Srivastava

Rakesh Maurya

Affiliations

Soon will be listed here.

Abstract

Eleven antidiabetic Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. Antidiabetic principles from five plants were isolated. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with standard drug metformin. Some compounds were also screened in db/db mice. Two compounds (PP-1 and PP-2) inhibited significantly the activity of PTPase-1B in an in vitro system. This might be the underlying mechanism of antihyperglycemic activity of these compounds.

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