Mannitol-enhanced Delivery of Stem Cells and Their Growth Factors Across the Blood-brain Barrier

Overview

Journal Cell Transplant

Specialties Cell Biology
General Surgery

Date 2014 Feb 1

PMID 24480552

Citations 38

Authors

Gabriel S Gonzales-Portillo

Paul R Sanberg

Max Franzblau

Chiara Gonzales-Portillo

Theo Diamandis

Meaghan Staples

Cyndy D Sanberg

Cesar V Borlongan

Affiliations

Soon will be listed here.

Abstract

Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells from embryo, fetus, perinatal, and adult tissues have proved effective in preclinical and small clinical trials. However, a limiting factor in the success of these treatments is the delivery of the cells and their by-products (neurotrophic factors) into the injured brain. We have demonstrated that mannitol, a drug with the potential to transiently open the blood-brain barrier and facilitate the entry of stem cells and trophic factors, as a solution to the delivery problem. The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.

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