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Neurocysticercosis: A Disease of Neglect

Overview
Journal Trop Parasitol
Specialty Parasitology
Date 2014 Jan 29
PMID 24470993
Citations 10
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Abstract

Neurocysticercosis (NCC) is a neglected tropical disease caused by larval forms of the parasite Taenia solium lodging in central nervous system (CNS). There is a huge morbidity and debilitation due to CNS manifestations of NCC in developing and underdeveloped regions of the globe, mainly Asian, African and Latin American countries. It is the cause of epilepsy in about 1% of the population of endemic countries and is the underlying etiology in about 15-50% persons with epilepsy, depending upon the geographical region. There is no perfect diagnostic method and the diagnosis relies on a combination of clinical, radio-imaging, immunologic and epidemiologic data. Treatment includes anti-parasitic treatment by cysticidal drugs and management of associated symptoms and complications. The disease is eradicable and control depends on an integrated and coordinated involvement of international bodies like the World Health Organization along with scientific institutions and political and administrative strata of the endemic countries to provide the essential tools such as adequate sanitation, live-stock management, health education and improved socio-economic conditions.

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References
1.
Osborn A, Preece M . Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology. 2006; 239(3):650-64. DOI: 10.1148/radiol.2393050823. View

2.
Del Brutto O, Roos K, Coffey C, Garcia H . Meta-analysis: Cysticidal drugs for neurocysticercosis: albendazole and praziquantel. Ann Intern Med. 2006; 145(1):43-51. DOI: 10.7326/0003-4819-145-1-200607040-00009. View

3.
Parija S, Balamurungan N, Sahu P, Subbaiah S . Cysticercus antibodies and antigens in serum from blood donors from Pondicherry, India. Rev Inst Med Trop Sao Paulo. 2005; 47(4):227-30. DOI: 10.1590/s0036-46652005000400010. View

4.
Coyle C, Mahanty S, Zunt J, Wallin M, Cantey P, White Jr A . Neurocysticercosis: neglected but not forgotten. PLoS Negl Trop Dis. 2012; 6(5):e1500. PMC: 3362619. DOI: 10.1371/journal.pntd.0001500. View

5.
Fleury A, Morales J, Bobes R, Dumas M, Yanez O, Pina J . An epidemiological study of familial neurocysticercosis in an endemic Mexican community. Trans R Soc Trop Med Hyg. 2005; 100(6):551-8. DOI: 10.1016/j.trstmh.2005.08.008. View