Ferromagnetic Nanoparticles with Peroxidase-like Activity Enhance the Cleavage of Biological Macromolecules for Biofilm Elimination

Overview

Journal Nanoscale

Specialty Biotechnology

Date 2014 Jan 29

PMID 24468900

Citations 56

Authors

Lizeng Gao

Krista M Giglio

Jacquelyn L Nelson

Holger Sondermann

Alexander J Travis

Affiliations

Soon will be listed here.

Abstract

Hydrogen peroxide (H2O2) is a "green chemical" that has various cleaning and disinfectant uses, including as an anti-bacterial agent for hygienic and medical treatments. However, its efficacy is limited against biofilm-producing bacteria, because of poor penetration into the protective, organic matrix. Here we show new applications for ferromagnetic nanoparticles (Fe3O4, MNPs) with peroxidase-like activity in potentiating the efficacy of H2O2 in biofilm degradation and prevention. Our data show that MNPs enhanced oxidative cleavage of biofilm components (model nucleic acids, proteins, and oligosaccharides) in the presence of H2O2. When challenged with live, biofilm-producing bacteria, the MNP-H2O2 system efficiently broke down the existing biofilm and prevented new biofilms from forming, killing both planktonic bacteria and those within the biofilm. By enhancing oxidative cleavage of various substrates, the MNP-H2O2 system provides a novel strategy for biofilm elimination, and other applications utilizing oxidative breakdown.

Citing Articles

A review of a colorimetric biosensor based on FeO nanozymes for food safety detection.

Guo N, Yang J, Li Y, Wang W, Liang X, Xu Q Anal Bioanal Chem. 2024; .

PMID: 39671070 DOI: 10.1007/s00216-024-05679-x.

Photovoltaic-driven stable electrosynthesis of HO in simulated seawater and its disinfection application.

Wen Y, Feng Y, Wei J, Zhang T, Cai C, Sun J Chem Sci. 2024; .

PMID: 39479170 PMC: 11514145. DOI: 10.1039/d4sc05909c.

Advancements in wound management: integrating nanotechnology and smart materials for enhanced therapeutic interventions.

Nasra S, Pramanik S, Oza V, Kansara K, Kumar A Discov Nano. 2024; 19(1):159.

PMID: 39354172 PMC: 11445205. DOI: 10.1186/s11671-024-04116-3.

A ruthenium single atom nanozyme-based antibiotic for the treatment of otitis media caused by .

Wang J, Gong R, Yang M, Wu X, Li Z, Huang H Front Chem. 2024; 12:1439039.

PMID: 39263587 PMC: 11387182. DOI: 10.3389/fchem.2024.1439039.

Alkaline phosphatase-activated prodrug system based on a bifunctional CuO NP tandem nanoenzyme for on-demand bacterial inactivation and wound disinfection.

Zhuang Q, Zhang Z, Zheng T, Lu L, Lin M, Yang J J Nanobiotechnology. 2024; 22(1):485.

PMID: 39138462 PMC: 11320994. DOI: 10.1186/s12951-024-02751-7.

References

Natalio F, Andre R, Hartog A, Stoll B, Jochum K, Wever R . Vanadium pentoxide nanoparticles mimic vanadium haloperoxidases and thwart biofilm formation. Nat Nanotechnol. 2012; 7(8):530-5. DOI: 10.1038/nnano.2012.91. View

Wang H, Huang Y . Prussian-blue-modified iron oxide magnetic nanoparticles as effective peroxidase-like catalysts to degrade methylene blue with H2O2. J Hazard Mater. 2011; 191(1-3):163-9. DOI: 10.1016/j.jhazmat.2011.04.057. View

Hall-Stoodley L, Costerton J, Stoodley P . Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol. 2004; 2(2):95-108. DOI: 10.1038/nrmicro821. View

Hoffman L, DArgenio D, MacCoss M, Zhang Z, Jones R, Miller S . Aminoglycoside antibiotics induce bacterial biofilm formation. Nature. 2005; 436(7054):1171-5. DOI: 10.1038/nature03912. View

Xu L, Wang J . Magnetic nanoscaled Fe3O4/CeO2 composite as an efficient Fenton-like heterogeneous catalyst for degradation of 4-chlorophenol. Environ Sci Technol. 2012; 46(18):10145-53. DOI: 10.1021/es300303f. View

Flemming H, Wingender J . The biofilm matrix. Nat Rev Microbiol. 2010; 8(9):623-33. DOI: 10.1038/nrmicro2415. View

Fan K, Cao C, Pan Y, Lu D, Yang D, Feng J . Magnetoferritin nanoparticles for targeting and visualizing tumour tissues. Nat Nanotechnol. 2012; 7(7):459-64. DOI: 10.1038/nnano.2012.90. View

Donlan R . Biofilms and device-associated infections. Emerg Infect Dis. 2001; 7(2):277-81. PMC: 2631701. DOI: 10.3201/eid0702.010226. View

Cochran W, McFeters G, Stewart P . Reduced susceptibility of thin Pseudomonas aeruginosa biofilms to hydrogen peroxide and monochloramine. J Appl Microbiol. 2000; 88(1):22-30. DOI: 10.1046/j.1365-2672.2000.00825.x. View

10.

Davies D . Understanding biofilm resistance to antibacterial agents. Nat Rev Drug Discov. 2003; 2(2):114-22. DOI: 10.1038/nrd1008. View

11.

Kim M, Ye Y, Woo M, Lee J, Park H . A highly efficient colorimetric immunoassay using a nanocomposite entrapping magnetic and platinum nanoparticles in ordered mesoporous carbon. Adv Healthc Mater. 2013; 3(1):36-41. DOI: 10.1002/adhm.201300100. View

12.

Wei H, Wang E . Fe3O4 magnetic nanoparticles as peroxidase mimetics and their applications in H2O2 and glucose detection. Anal Chem. 2008; 80(6):2250-4. DOI: 10.1021/ac702203f. View

13.

Mah T, OToole G . Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 2001; 9(1):34-9. DOI: 10.1016/s0966-842x(00)01913-2. View

14.

Yu F, Huang Y, Cole A, Yang V . The artificial peroxidase activity of magnetic iron oxide nanoparticles and its application to glucose detection. Biomaterials. 2009; 30(27):4716-22. PMC: 3252767. DOI: 10.1016/j.biomaterials.2009.05.005. View

15.

Liu S, Lu F, Xing R, Zhu J . Structural effects of Fe3O4 nanocrystals on peroxidase-like activity. Chemistry. 2011; 17(2):620-5. DOI: 10.1002/chem.201001789. View

16.

Zhang S, Zhao X, Niu H, Shi Y, Cai Y, Jiang G . Superparamagnetic Fe3O4 nanoparticles as catalysts for the catalytic oxidation of phenolic and aniline compounds. J Hazard Mater. 2009; 167(1-3):560-6. DOI: 10.1016/j.jhazmat.2009.01.024. View

17.

OToole G, Kolter R . Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis. Mol Microbiol. 1998; 28(3):449-61. DOI: 10.1046/j.1365-2958.1998.00797.x. View

18.

Francolini I, Donelli G . Prevention and control of biofilm-based medical-device-related infections. FEMS Immunol Med Microbiol. 2010; 59(3):227-38. DOI: 10.1111/j.1574-695X.2010.00665.x. View

19.

Wei H, Wang E . Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem Soc Rev. 2013; 42(14):6060-93. DOI: 10.1039/c3cs35486e. View

20.

Taylor E, Webster T . Reducing infections through nanotechnology and nanoparticles. Int J Nanomedicine. 2011; 6:1463-73. PMC: 3141873. DOI: 10.2147/IJN.S22021. View