» Articles » PMID: 24459268

Draft Genome Sequence of the Microbispora Sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107

Overview
Journal Genome Announc
Date 2014 Jan 25
PMID 24459268
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

We report the draft genome sequence of Microbispora sp. strain ATCC-PTA-5024, a soil isolate that produces NAI-107, a new lantibiotic with the potential to treat life-threatening infections caused by multidrug-resistant Gram-positive pathogens. The draft genome of strain Microbispora sp. ATCC-PTA-5024 consists of 8,543,819 bp, with a 71.2% G+C content and 7,860 protein-coding genes.

Citing Articles

New developments in RiPP discovery, enzymology and engineering.

Montalban-Lopez M, Scott T, Ramesh S, Rahman I, van Heel A, Viel J Nat Prod Rep. 2020; 38(1):130-239.

PMID: 32935693 PMC: 7864896. DOI: 10.1039/d0np00027b.


Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.

Ortega M, Hao Y, Walker M, Donadio S, Sosio M, Nair S Cell Chem Biol. 2016; 23(3):370-380.

PMID: 26877024 PMC: 4798866. DOI: 10.1016/j.chembiol.2015.11.017.


Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024.

Gallo G, Renzone G, Palazzotto E, Monciardini P, Arena S, Faddetta T BMC Genomics. 2016; 17:42.

PMID: 26754974 PMC: 4709908. DOI: 10.1186/s12864-016-2369-z.


A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete.

Tocchetti A, Bordoni R, Gallo G, Petiti L, Corti G, Alt S PLoS One. 2015; 10(7):e0133705.

PMID: 26207753 PMC: 4514598. DOI: 10.1371/journal.pone.0133705.


A relA-dependent regulatory cascade for auto-induction of microbisporicin production in Microbispora corallina.

Fernandez-Martinez L, Gomez-Escribano J, Bibb M Mol Microbiol. 2015; 97(3):502-14.

PMID: 25939852 PMC: 4973701. DOI: 10.1111/mmi.13046.


References
1.
Jabes D, Brunati C, Candiani G, Riva S, Romano G, Donadio S . Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens. Antimicrob Agents Chemother. 2011; 55(4):1671-6. PMC: 3067139. DOI: 10.1128/AAC.01288-10. View

2.
Blin K, Medema M, Kazempour D, Fischbach M, Breitling R, Takano E . antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 2013; 41(Web Server issue):W204-12. PMC: 3692088. DOI: 10.1093/nar/gkt449. View

3.
Bennett S . Solexa Ltd. Pharmacogenomics. 2004; 5(4):433-8. DOI: 10.1517/14622416.5.4.433. View

4.
Foulston L, Bibb M . Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes. Proc Natl Acad Sci U S A. 2010; 107(30):13461-6. PMC: 2922176. DOI: 10.1073/pnas.1008285107. View

5.
Medema M, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach M . antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res. 2011; 39(Web Server issue):W339-46. PMC: 3125804. DOI: 10.1093/nar/gkr466. View