The AML1/ETO Target Gene LAT2 Interferes with Differentiation of Normal Hematopoietic Precursor Cells

Overview

Journal Leuk Res

Date 2014 Jan 25

PMID 24456692

Citations 4

Authors

Aitomi Essig

Jesus Duque-Afonso

Sven Schwemmers

Heike L Pahl

Michael Lubbert

Affiliations

Soon will be listed here.

Abstract

The adaptor protein linker activator of T-cells 2 (LAT2) is a known AML1/ETO target gene whose function during normal hematopoiesis is unknown. We addressed the role of LAT2 during erythroid and myeloid differentiation of normal human CD34+ hematopoietic cells. LAT2 is expressed at low levels in CD34+ cells and upregulated during cytokine-induced myeloid and erythroid differentiation. Forced LAT2 expression leads to a delay of erythroid and myeloid differentiation keeping CD34+ cells in a more immature state, whereas LAT2 knockdown accelerates differentiation. It is tempting to speculate that by affecting the differentiation capacity of normal hematopoietic progenitors, LAT2 may contribute to the pathogenesis of AML.

Citing Articles

AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms.

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NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia.

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Runx1t1 promotes the neuronal differentiation in rat hippocampus.

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Subtype-specific regulatory network rewiring in acute myeloid leukemia.

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