Is Vitamin D Insufficiency Associated with Mortality of Critically Ill Patients?

Overview

Journal Crit Care Res Pract

Publisher Wiley

Specialty Critical Care

Date 2014 Jan 24

PMID 24455224

Citations 21

Authors

Gulbin Aygencel

Melda Turkoglu

Ayse Fitnat Tuncel

Burcu Arslan Candir

Yelda Deligoz Bildaci

Hatice Pasaoglu

Affiliations

Soon will be listed here.

Abstract

Objective. To evaluate the vitamin D status of our critically ill patients and its relevance to mortality. Patients and Methods. We performed a prospective observational study in the medical intensive care unit of a university hospital between October 2009 and March 2011. Vitamin D levels were measured and insufficiency was defined as <20 ng/mL. Results. Two hundred and one patients were included in the study. The median age was 66 (56-77) and the majority of patients were male (56%). The median serum level of vitamin D was 14,9 ng/mL and 139 (69%) patients were vitamin D insufficient on admission. While we grouped the ICU patients as vitamin D insufficient and sufficient, vitamin D insufficient patients had more severe acute diseases and worse laboratory values on admission. These patients had more morbidities and were exposed to more invasive therapies during stay. The mortality rate was significantly higher in the vitamin D insufficient group compared to the vitamin D sufficient group (43% versus 26%, P = 0,027). However, logistic regression analysis demonstrated that vitamin D insufficiency was not an independent risk factor for mortality. Conclusion. Vitamin D insufficiency is common in our critically ill patients (69%), but it is not an independent risk factor for mortality.

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