Update in Vitamin D

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2010 Feb 6

PMID 20133466

Citations 313

Authors

John S Adams

Martin Hewison

Affiliations

Soon will be listed here.

Abstract

The past decade, particularly the last 18 months, witnessed a vigorous increase in interest in vitamin D from both the lay and biomedical worlds. Much of the growing interest in vitamin D is powered by new data being extracted from the National Health and Nutrition Examination Survey (NHANES). The newest statistics demonstrate that more than 90% of the pigmented populace of the United States (Blacks, Hispanics, and Asians) now suffer from vitamin D insufficiency (25-hydroxyvitamin D <30 ng/ml), with nearly three fourths of the white population in this country also being vitamin D insufficient. This represents a near doubling of the prevalence of vitamin D insufficiency seen just 10 yr ago in the same population. This review attempts to provide some explanation for: 1) the rapid decline in vitamin D status in the United States; 2) the adverse impact of vitamin D insufficiency on skeletal, infectious/inflammatory, and metabolic health in humans; and 3) the therapeutic rationale and reliable means for vigorous supplementation of our diets with vitamin D.

Citing Articles

Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis.

Kawada K, Sato C, Ishida T, Nagao Y, Yamamoto T, Jobu K Medicina (Kaunas). 2025; 61(2).

PMID: 40005471 PMC: 11857834. DOI: 10.3390/medicina61020355.

Hereditary disorders of vitamin-D metabolism and its receptor.

Lainis V, Katsouli O, Gazi S, Kassi E, Chronopoulos E, Tournis S Hormones (Athens). 2025; .

PMID: 39893280 DOI: 10.1007/s42000-025-00630-w.

A Prospective Study of Nephrocalcinosis in Very Preterm Infants: Incidence, Risk Factors and Vitamin D Intake in the First Month.

Garunkstiene R, Levuliene R, Cekuolis A, Cerkauskiene R, Drazdiene N, Liubsys A Medicina (Kaunas). 2025; 60(12.

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1,25(OH)2D3 increase osteogenic potential of human periodontal ligament cells with low osteoblast potential.

Pereira B, Sacramento C, Sallum E, Monteiro M, Casarin R, Casati M J Appl Oral Sci. 2024; 32:e20240160.

PMID: 39607248 PMC: 11657088. DOI: 10.1590/1678-7757-2024-0160.

A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine-related disorders.

Rosli N, Mohd Nor N, Adnan R, Sheikh Abdul Kadir S Clin Exp Pediatr. 2024; 68(1):30-52.

PMID: 39533737 PMC: 11725620. DOI: 10.3345/cep.2024.00227.

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