Structures of Soluble Guanylate Cyclase: Implications for Regulatory Mechanisms and Drug Development

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2014 Jan 24

PMID 24450636

Citations 11

Authors

Opher Gileadi

Affiliations

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Abstract

Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.

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