Synthesis of a Miniature Lipoarabinomannan

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2014 Jan 22

PMID 24444032

Citations 4

Authors

Jian Gao

Guochao Liao

Lizhen Wang

Zhongwu Guo

Affiliations

Soon will be listed here.

Abstract

An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies.

Citing Articles

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Flores J, Cancino J, Chavez-Galan L Front Microbiol. 2021; 12:638047.

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Expedient synthesis of the heneicosasaccharyl mannose capped arabinomannan of the cellular envelope by glycosyl carbonate donors.

Islam M, Shinde G, Hotha S Chem Sci. 2017; 8(3):2033-2038.

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[Au]/[Ag]-catalysed expedient synthesis of branched heneicosafuranosyl arabinogalactan motif of Mycobacterium tuberculosis cell wall.

Thadke S, Mishra B, Islam M, Pasari S, Manmode S, Rao B Nat Commun. 2017; 8:14019.

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Chemical Synthesis of the Repeating Unit of Type V Group B Streptococcus Capsular Polysaccharide.

Gao J, Guo Z Org Lett. 2016; 18(21):5552-5555.

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