The Immunomodulatory Lipoglycans, Lipoarabinomannan and Lipomannan, Are Exposed at the Mycobacterial Cell Surface

Overview

Journal Tuberculosis (Edinb)

Specialties Infectious Diseases
Pulmonary Medicine

Date 2008 Jun 10

PMID 18539533

Citations 49

Authors

Sylvain Pitarque

Gerald Larrouy-Maumus

Bruno Payre

Mary Jackson

Germain Puzo

Jerome Nigou

Affiliations

Soon will be listed here.

Abstract

By labeling surface carbohydrates, we found that a pool of lipoglycans, cell wall associated, is exposed at the cell surface of mycobacteria and thus, most probably, inserted in the outer leaflet of the outer membrane. In contrast, plasma membrane anchored lipoglycans are not accessible to surface labeling. This result supports the role of lipoglycans as key immunomodulatory molecules but raises the question of their transport from the plasma membrane, where they are synthesized, to the outermost layers of the envelope, where they can act as modulins. The data are discussed in terms of consequences for cell envelope organization.

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