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RECONSTRUCTION OF THE HUMAN HIPPOCAMPUS IN 3D FROM HISTOLOGY AND HIGH-RESOLUTION EX-VIVO MRI

Overview
Journal Proc IEEE Int Symp Biomed Imaging
Publisher IEEE
Date 2014 Jan 21
PMID 24443672
Citations 5
Authors
Daniel H Adler
Alex Yang Liu
John Pluta
Salmon Kadivar
Sylvia Orozco
Hongzhi Wang
James C Gee
Brian B Avants
Paul A Yushkevich
Affiliations
Soon will be listed here.
Abstract

In this paper, we present methods for the reconstruction of 3D histological volumes of the human hippocampal formation from histology slices. Inter-slice alignment is guided by a graph-theoretic approach that minimizes the impact of badly distorted slices. The reconstruction is refined by iterative affine and deformable co-registration with a high-resolution MRI of the postmortem tissue sample. We present an evaluation of reconstruction accuracy that is based on measures of similarity between boundaries drawn on both histology and MRI. Our methodology is currently being applied to an MRI atlas of the human hippocampal formation, in which atlas anatomical labels are derived from segmentation of reconstructed histology.

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