Krüppel-like Factors in Cancer Progression: Three Fingers on the Steering Wheel

Overview

Journal Oncotarget

Specialty Oncology

Date 2014 Jan 17

PMID 24429391

Citations 36

Authors

Ridha Limame

Ken Op de Beeck

Filip Lardon

Olivier de Wever

Patrick Pauwels

Affiliations

Soon will be listed here.

Abstract

Krüppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency. During the last few years, evidence on their role and deregulation in different human cancers has been emerging. This review will discuss current knowledge on Krüppel-like transcription in the epithelial-mesenchymal transition (EMT), invasion and metastasis, with a focus on epithelial cancer biology and the extensive interface with pluripotency. Furthermore, as KLFs are able to mediate different outcomes, important influences of the cellular and microenvironmental context will be highlighted. Finally, we attempt to integrate diverse findings on KLF functions in EMT and stem cell biology to fit in the current model of cellular plasticity as a tool for successful metastatic dissemination.

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