Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2020 Feb 6

PMID 32019121

Citations 3

Authors

Yi-Ju Lee

Lung Chan

Chung-Min Yeh

Chien-Hsun Lee

Wen-Wei Sung

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC.

Materials And Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan-Meier analysis and Cox proportional hazard models.

Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low -value ( = 0.033 and = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034-2.191, = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low -value.

Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low -value.

Citing Articles

High Expression of MTA1 Predicts Unfavorable Survival in Patients With Oral Squamous Cell Carcinoma.

Lin K, Su T, Yeh C, Chao W, Sung W In Vivo. 2021; 35(4):2363-2368.

PMID: 34182519 PMC: 8286510. DOI: 10.21873/invivo.12513.

High Expression of KLF10 Is Associated with Favorable Survival in Patients with Oral Squamous Cell Carcinoma.

Yeh C, Lee Y, Ko P, Lin Y, Sung W Medicina (Kaunas). 2020; 57(1).

PMID: 33379261 PMC: 7824494. DOI: 10.3390/medicina57010017.

KLF7: a new candidate biomarker and therapeutic target for high-grade serous ovarian cancer.

De Donato M, Babini G, Mozzetti S, Buttarelli M, Ciucci A, Arduini G J Exp Clin Cancer Res. 2020; 39(1):265.

PMID: 33250051 PMC: 7702713. DOI: 10.1186/s13046-020-01775-9.

References

McConnell B, Yang V . Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010; 90(4):1337-81. PMC: 2975554. DOI: 10.1152/physrev.00058.2009. View

Zhang L, Meng X, Zhu X, Yang D, Chen R, Jiang Y . Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications. Mol Cancer. 2019; 18(1):102. PMC: 6535863. DOI: 10.1186/s12943-019-1021-3. View

Tetreault M, Yang Y, Katz J . Krüppel-like factors in cancer. Nat Rev Cancer. 2013; 13(10):701-13. DOI: 10.1038/nrc3582. View

Sung W, Wang Y, Cheng Y, Lee M, Yeh K, Wang L . A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer. Clin Cancer Res. 2011; 17(18):5991-9. DOI: 10.1158/1078-0432.CCR-11-0227. View

Peng J, Wu B, Xiao X, Shao Y, Feng Y, Yin M . Reduced Krüppel-like factor 17 (KLF17) expression correlates with poor survival in patients with gastric cancer. Arch Med Res. 2014; 45(5):394-9. DOI: 10.1016/j.arcmed.2014.06.005. View

Camacho-Vanegas O, Narla G, Teixeira M, DiFeo A, Misra A, Singh G . Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma. Int J Cancer. 2007; 121(6):1390-5. DOI: 10.1002/ijc.22809. View

Cai X, Zhou Y, Huang L, Zeng Q, Zhang L, Wang Q . Reduced expression of Krüppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. Biochem Biophys Res Commun. 2012; 418(1):67-73. DOI: 10.1016/j.bbrc.2011.12.129. View

Sung W, Lin Y, Wu P, Yen H, Lai H, Su T . High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients. BMC Cancer. 2014; 14:951. PMC: 4302138. DOI: 10.1186/1471-2407-14-951. View

Zhou S, Tang X, Tang F . Krüppel-like factor 17, a novel tumor suppressor: its low expression is involved in cancer metastasis. Tumour Biol. 2015; 37(2):1505-13. PMC: 4842221. DOI: 10.1007/s13277-015-4588-3. View

10.

Hwang J, Sung W, Tu H, Hsieh K, Yeh C, Chen C . The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma. PLoS One. 2015; 10(10):e0139435. PMC: 4592204. DOI: 10.1371/journal.pone.0139435. View

11.

Ye W, Gao L, Huang J, Fang X, Xie G . Suppressed Krüppel‑like factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma. Mol Med Rep. 2014; 10(4):2087-92. DOI: 10.3892/mmr.2014.2429. View

12.

Lu X, Shi Y, Chen J, Ma S . Krüppel-like factors in hepatocellular carcinoma. Tumour Biol. 2015; 36(2):533-41. DOI: 10.1007/s13277-015-3127-6. View

13.

Ferlazzo N, Curro M, Zinellu A, Caccamo D, Isola G, Ventura V . Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer. Int J Mol Sci. 2017; 18(4). PMC: 5412310. DOI: 10.3390/ijms18040724. View

14.

Gao H, Zhou N, Sun Z, Dou X, Guan M, Bai C . KLF17 Expression in Colorectal Carcinoma and Its Clinical Significance. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016; 38(1):69-72. DOI: 10.3881/j.issn.1000-503X.2016.01.012. View

15.

Dumache R, Rogobete A, Andreescu N, Puiu M . Genetic and Epigenetic Biomarkers of Molecular Alterations in Oral Carcinogenesis. Clin Lab. 2015; 61(10):1373-81. DOI: 10.7754/clin.lab.2015.150327. View

16.

Kale A, Angadi P . Tumor budding is a potential histopathological marker in the prognosis of oral squamous cell carcinoma: Current status and future prospects. J Oral Maxillofac Pathol. 2020; 23(3):318-323. PMC: 6948063. DOI: 10.4103/jomfp.JOMFP_331_19. View

17.

Ali A, Bhatti M, Shah A, Duong H, Alkreathy H, Mohammad S . Tumor-suppressive p53 Signaling Empowers Metastatic Inhibitor KLF17-dependent Transcription to Overcome Tumorigenesis in Non-small Cell Lung Cancer. J Biol Chem. 2015; 290(35):21336-51. PMC: 4571863. DOI: 10.1074/jbc.M114.635730. View

18.

Liu F, Deng Y, Li Y, Zeng D, Zhou Z, Tian D . Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma. Med Oncol. 2013; 30(1):425. DOI: 10.1007/s12032-012-0425-3. View

19.

van Vliet J, Crofts L, Quinlan K, Czolij R, Perkins A, Crossley M . Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics. 2006; 87(4):474-82. DOI: 10.1016/j.ygeno.2005.12.011. View

20.

Matarese G, Curro M, Isola G, Caccamo D, Vecchio M, Giunta M . Transglutaminase 2 up-regulation is associated with RANKL/OPG pathway in cultured HPDL cells and THP-1-differentiated macrophages. Amino Acids. 2015; 47(11):2447-55. DOI: 10.1007/s00726-015-2039-5. View