Characterization of the Congeners in the Lantibiotic NAI-107 Complex

Overview

Journal J Nat Prod

Date 2014 Jan 16

PMID 24422756

Citations 21

Authors

Sonia I Maffioli

Marianna Iorio

Margherita Sosio

Paolo Monciardini

Eleonora Gaspari

Stefano Donadio

Affiliations

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Abstract

NAI-107, a lantibiotic produced by Microbispora sp. 107891, shows potent activity against multi-drug-resistant bacterial pathogens. It is produced as a complex of related molecules, which is unusual for ribosomally synthesized peptides. Here we describe the identification, characterization, and antibacterial activity of the congeners produced by Microbispora sp. 107891 and by the related Microbispora corallina NRRL 30420. These molecules differ by the presence of two, one, or zero hydroxyl groups at Pro-14, by the presence of a chlorine at Trp-4, and/or by the presence of a sulfoxide on the thioether of the first lanthionine.

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