Bacterial RNA Polymerases: Structural and Functional Relationships

Overview

Journal World J Microbiol Biotechnol

Publisher Springer

Specialties Biotechnology
Microbiology

Date 2014 Jan 15

PMID 24420107

Citations 1

Authors

R E Glass

R S Hayward

Affiliations

Soon will be listed here.

Abstract

The essential role of DNA-dependent RNA polymerases in gene expression and the fact that the multimeric species are highly conserved throughout nature makes these enzymes a particular fascinating area of study. Here we shall review the conservation of structures and their relationship to function, especially in the multimeric eubacterial RNA polymerases, paying particular attention to the β core subunit and to recent studies of σ-factors of both the σ (70) and σ (54) families. We shall conclude with a brief consideration of phage-encoded RNA polymerases and phage-mediated modification of the host enzyme, and of the evolution of RNA-synthesising enzymes.

Citing Articles

The RNA polymerase alpha subunit from Sinorhizobium meliloti can assemble with RNA polymerase subunits from Escherichia coli and function in basal and activated transcription both in vivo and in vitro.

Peck M, Gaal T, Fisher R, Gourse R, Long S J Bacteriol. 2002; 184(14):3808-14.

PMID: 12081950 PMC: 135166. DOI: 10.1128/JB.184.14.3808-3814.2002.

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