Surgery in Lumbar Degenerative Spondylolisthesis: Indications, Outcomes and Complications. A Systematic Review

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2014 Jan 10

PMID 24402446

Citations 42

Authors

F Steiger

H-J Becker

C J Standaert

F Balague

J-P Vader

F Porchet

A F Mannion

Affiliations

Soon will be listed here.

Abstract

Purpose: This systematic review summarises the literature on patient selection, decision-making, effectiveness and outcomes in the surgical treatment of lumbar degenerative spondylolisthesis (LDS).

Introduction: In daily practice, decision-making in the treatment of LDS is challenging. There is little consensus on either the precise indications or prognostic factors for any specific therapy (operative or non-operative).

Methods: We searched for LDS trials published between 01.01.1990 and 16.11.2011 in Medline, Embase, Cochrane Library and Cinahl. Two independent reviewers selected studies according to the inclusion criteria. Data were then extracted by two of the authors. Quality assessment was performed using the Downs and Black list for the clinical trials/studies and AMSTAR for the reviews.

Results:

Data Synthesis: 21 papers met the inclusion criteria (2 studies comprising both a RCT and a concurrent observational analysis, 1 RCT, 6 prospective studies, 8 retrospective studies, 3 reviews, 1 review guideline). The quality of the clinical studies was on average "fair" [mean score 15.6 points (range 10-19) out of 24 points (Downs and Black)]. The quality of the reviews ranged from 1 to 7 out of 11 points with an average of 5 points (AMSTAR). The study outcomes could not be subject to meta-analysis due to heterogeneity of study design and variable measure used.

Conclusions: Despite there being many articles describing and/or comparing different surgical options for LDS, there was insufficient evidence to draw conclusions concerning clear indications for specific types of surgical treatment, predictors of outcome or complication rates. There remains a need to establish a decision-making tool to facilitate daily clinical practice and to assure appropriate treatment for patients with LDS.

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References

Sears W . Posterior lumbar interbody fusion for degenerative spondylolisthesis: restoration of sagittal balance using insert-and-rotate interbody spacers. Spine J. 2005; 5(2):170-9. DOI: 10.1016/j.spinee.2004.05.257. View

ORourke M, Grobler L . L4-L5 degenerative spondylolisthesis: indications and technique for operative management. Iowa Orthop J. 1998; 18:76-86. PMC: 2378167. View

Watters 3rd W, Bono C, Gilbert T, Kreiner D, Mazanec D, Shaffer W . An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spondylolisthesis. Spine J. 2009; 9(7):609-14. DOI: 10.1016/j.spinee.2009.03.016. View

Carreon L, Puno R, Dimar 2nd J, Glassman S, Johnson J . Perioperative complications of posterior lumbar decompression and arthrodesis in older adults. J Bone Joint Surg Am. 2003; 85(11):2089-92. DOI: 10.2106/00004623-200311000-00004. View

Weinstein J, Lurie J, Tosteson T, Zhao W, Blood E, Tosteson A . Surgical compared with nonoperative treatment for lumbar degenerative spondylolisthesis. four-year results in the Spine Patient Outcomes Research Trial (SPORT) randomized and observational cohorts. J Bone Joint Surg Am. 2009; 91(6):1295-304. PMC: 2686131. DOI: 10.2106/JBJS.H.00913. View

Bridwell K, Sedgewick T, OBrien M, Lenke L, Baldus C . The role of fusion and instrumentation in the treatment of degenerative spondylolisthesis with spinal stenosis. J Spinal Disord. 1993; 6(6):461-72. DOI: 10.1097/00002517-199306060-00001. View

Ghogawala Z, Benzel E, Amin-Hanjani S, Barker 2nd F, Harrington J, Magge S . Prospective outcomes evaluation after decompression with or without instrumented fusion for lumbar stenosis and degenerative Grade I spondylolisthesis. J Neurosurg Spine. 2004; 1(3):267-72. DOI: 10.3171/spi.2004.1.3.0267. View

Mardjetko S, Connolly P, Shott S . Degenerative lumbar spondylolisthesis. A meta-analysis of literature 1970-1993. Spine (Phila Pa 1976). 1994; 19(20 Suppl):2256S-2265S. View

Xu H, Tang H, Li Z . Surgical treatment of adult degenerative spondylolisthesis by instrumented transforaminal lumbar interbody fusion in the Han nationality. J Neurosurg Spine. 2009; 10(5):496-9. DOI: 10.3171/2009.2.SPINE08623. View

10.

Kalichman L, Hunter D . Diagnosis and conservative management of degenerative lumbar spondylolisthesis. Eur Spine J. 2007; 17(3):327-335. PMC: 2270383. DOI: 10.1007/s00586-007-0543-3. View

11.

Herkowitz H, Kurz L . Degenerative lumbar spondylolisthesis with spinal stenosis. A prospective study comparing decompression with decompression and intertransverse process arthrodesis. J Bone Joint Surg Am. 1991; 73(6):802-8. View

12.

Abdul Q, Qayum M, Saradhi M, Panigrahi M, Sreedhar V . Clinico-radiological profile of indirect neural decompression using cage or auto graft as interbody construct in posterior lumbar interbody fusion in spondylolisthesis: Which is better?. J Craniovertebr Junction Spine. 2011; 2(1):12-6. PMC: 3190424. DOI: 10.4103/0974-8237.85308. View

13.

Abdu W, Lurie J, Spratt K, Tosteson A, Zhao W, Tosteson T . Degenerative spondylolisthesis: does fusion method influence outcome? Four-year results of the spine patient outcomes research trial. Spine (Phila Pa 1976). 2009; 34(21):2351-60. PMC: 3750746. DOI: 10.1097/BRS.0b013e3181b8a829. View

14.

Yan D, Pei F, Li J, Soo C . Comparative study of PILF and TLIF treatment in adult degenerative spondylolisthesis. Eur Spine J. 2008; 17(10):1311-6. PMC: 2556474. DOI: 10.1007/s00586-008-0739-1. View

15.

Sengupta D, Herkowitz H . Degenerative spondylolisthesis: review of current trends and controversies. Spine (Phila Pa 1976). 2005; 30(6 Suppl):S71-81. DOI: 10.1097/01.brs.0000155579.88537.8e. View

16.

Fischgrund J . The argument for instrumented decompressive posterolateral fusion for patients with degenerative spondylolisthesis and spinal stenosis. Spine (Phila Pa 1976). 2004; 29(2):173-4. DOI: 10.1097/01.BRS.0000111142.76601.1A. View

17.

Boden S, Riew K, Yamaguchi K, Branch T, Schellinger D, Wiesel S . Orientation of the lumbar facet joints: association with degenerative disc disease. J Bone Joint Surg Am. 1996; 78(3):403-11. DOI: 10.2106/00004623-199603000-00012. View

18.

Fischgrund J, Mackay M, Herkowitz H, Brower R, MONTGOMERY D, Kurz L . 1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation. Spine (Phila Pa 1976). 1998; 22(24):2807-12. DOI: 10.1097/00007632-199712150-00003. View

19.

Weinstein J, Lurie J, Tosteson T, Hanscom B, Tosteson A, Blood E . Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis. N Engl J Med. 2007; 356(22):2257-70. PMC: 2553804. DOI: 10.1056/NEJMoa070302. View

20.

Downs S, Black N . The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998; 52(6):377-84. PMC: 1756728. DOI: 10.1136/jech.52.6.377. View