Non-enhanced MR Imaging of Cerebral Aneurysms: 7 Tesla Versus 1.5 Tesla

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jan 9

PMID 24400100

Citations 22

Authors

Karsten H Wrede

Philipp Dammann

Christoph Monninghoff

Soren Johst

Stefan Maderwald

I Erol Sandalcioglu

Oliver Muller

Neriman Ozkan

Mark E Ladd

Michael Forsting

Marc U Schlamann

Ulrich Sure

Lale Umutlu

Affiliations

Soon will be listed here.

Abstract

Purpose: To prospectively evaluate 7 Tesla time-of-flight (TOF) magnetic resonance angiography (MRA) in comparison to 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for delineation of unruptured intracranial aneurysms (UIA).

Material And Methods: Sixteen neurosurgical patients (male n = 5, female n = 11) with single or multiple UIA were enrolled in this trial. All patients were accordingly examined at 7 Tesla and 1.5 Tesla MRI utilizing dedicated head coils. The following sequences were obtained: 7 Tesla TOF MRA, 1.5 Tesla TOF MRA and 7 Tesla non-contrast enhanced MPRAGE. Image analysis was performed by two radiologists with regard to delineation of aneurysm features (dome, neck, parent vessel), presence of artifacts, vessel-tissue-contrast and overall image quality. Interobserver accordance and intermethod comparisons were calculated by kappa coefficient and Lin's concordance correlation coefficient.

Results: A total of 20 intracranial aneurysms were detected in 16 patients, with two patients showing multiple aneurysms (n = 2, n = 4). Out of 20 intracranial aneurysms, 14 aneurysms were located in the anterior circulation and 6 aneurysms in the posterior circulation. 7 Tesla MPRAGE imaging was superior over 1.5 and 7 Tesla TOF MRA in the assessment of all considered aneurysm and image quality features (e.g. image quality: mean MPRAGE7T: 5.0; mean TOF7T: 4.3; mean TOF1.5T: 4.3). Ratings for 7 Tesla TOF MRA were equal or higher over 1.5 Tesla TOF MRA for all assessed features except for artifact delineation (mean TOF7T: 4.3; mean TOF1.5T 4.4). Interobserver accordance was good to excellent for most ratings.

Conclusion: 7 Tesla MPRAGE imaging demonstrated its superiority in the detection and assessment of UIA as well as overall imaging features, offering excellent interobserver accordance and highest scores for all ratings. Hence, it may bear the potential to serve as a high-quality diagnostic tool for pretherapeutic assessment and follow-up of untreated UIA.

Citing Articles

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Diagnosis of Small Unruptured Intracranial Aneurysms : Comparison of 7 T versus 3 T MRI.

Radojewski P, Dobrocky T, Branca M, Almiri W, Correia M, Raabe A Clin Neuroradiol. 2023; 34(1):45-49.

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Tsutsui S, Matsuda T, Takeda K, Sasaki M, Kubo Y, Setta K AJNR Am J Neuroradiol. 2022; 43(7):972-977.

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Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye.

Maupu C, Lebas H, Boulaftali Y Front Cardiovasc Med. 2022; 9:793072.

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