Inhibitory Effects of Wall Ex Lindl. on Azoxymethane- and Dextran Sulfate Sodium-induced Colon Carcinogenesis in C57BL/6 Mice

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Jan 8

PMID 24396476

Citations 18

Authors

Qiang Wang

Peng Sun

Guijie Li

Kai Zhu

Cun Wang

Xin Zhao

Affiliations

Soon will be listed here.

Abstract

Wall ex Lindl. was purchased for the evaluation of azoxymethane (AOM)- and dextran sulfate sodium (DSS)-induced colon carcinogenesis in C57BL/6 mice. The body weights of the AOM- and DSS-induced colon cancer control groups were lighter than those of the untreated mice. increased the body weights of the mice compared with the control group, and reduced the levels of the serum proinflammatory cytokines, IL-6, IL-12, TNF-α and IFN-γ, compared with the colon cancer control group. Reverse transcription-polymerase chain reaction and western blot analyses of the apoptotic-related genes, bax, bcl-2, caspase-3 and caspase-9, were performed in the colon tissues. The high-concentration group showed a significant increase in the mRNA and protein expression levels of bax, caspase-3 and caspase-9 and decreased expression levels of bcl-2 compared with the control group. These results indicate that Wall ex Lindl. exhibits preventive effects against colon carcinogenesis in mice.

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