Preventive Effect of Wall. Ex Lindl. on Activated Carbon-induced Constipation in Mice

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2015 Jan 10

PMID 25574235

Citations 5

Authors

Rui Wang

Peng Sun

Yalin Zhou

Xin Zhao

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the effects of Wall. ex Lindl. () on activated carbon-induced constipation in ICR mice. ICR mice were orally administered for 9 days. Body weight, defecation status, gastrointestinal (GI) transit and defecation times, in addition to the levels of motilin (MTL), gastrin (Gas), endothelin (ET), somatostatin (SS), acetylcholinesterase (AChE), substance P (SP) and vasoactive intestinal peptide (VIP) in serum were used to evaluate the preventive effects of on constipation. The laxative drug bisacodyl acted as a positive control. The time to the first defecation of a black stool for the normal, control, bisacodyl-treated (100 mg/kg), 200 and 400 mg/kg -treated mice was 84, 202, 126, 161 and 142 min, respectively. Following the consumption of 200 and 400 mg/kg or bisacodyl (100 mg/kg), the GI transit was reduced to 57.7, 74.6 and 90.2%, respectively, of the transit in normal mice. The serum levels of MTL, Gas, ET, AChE, SP and VIP were significantly increased and the serum levels of SS were reduced in the mice treated with compared with those in the untreated control mice (P<0.05). These results demonstrate that has preventive effects on constipation in mice, and a greater functional activity was observed when a higher concentration was administered.

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