Endoplasmic Reticulum Stress and Angiogenesis: is There an Interaction Between Them?

Overview

Journal Liver Int

Specialty Gastroenterology

Date 2014 Jan 8

PMID 24393274

Citations 17

Authors

Annelies Paridaens

Debby Laukens

Yves-Paul Vandewynckel

Stephanie Coulon

Hans Van Vlierberghe

Anja Geerts

Isabelle Colle

Affiliations

Soon will be listed here.

Abstract

When cells are subjected to stress by changes in their extracellular environment, unfolded proteins accumulate in the endoplasmic reticulum (ER), causing ER stress. This initiates the unfolded protein response (UPR), a signal transduction cascade aiming at restoring cellular homeostasis. The UPR and angiogenesis are involved in the pathogenesis of many diseases such as cancer, pulmonary diseases and chronic liver diseases (CLDs) including alcoholic liver disease, non-alcoholic steatohepatitis and hepatitis B. This review summarizes the upcoming knowledge of the interaction between the UPR and angiogenesis in physiological angiogenesis and in different CLDs and other diseases.

Citing Articles

Endoplasmic Reticulum Stress in Hepatitis B Virus and Hepatitis C Virus Infection.

Hu T, Wang J, Li W, Liu M, Han N, Yuan M Viruses. 2022; 14(12).

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Inhibition of endoplasmic reticulum stress alleviates triple-negative breast cancer cell viability, migration, and invasion by Syntenin/SOX4/Wnt/β-catenin pathway via regulation of heat shock protein A4.

Nan J, Hu X, Guo B, Xu M, Yao Y Bioengineered. 2022; 13(4):10564-10577.

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Duck enteritis virus infection suppresses viability and induces apoptosis and endoplasmic reticulum stress in duck embryo fibroblast cells via the regulation of Ca.

Zhang Y, Wang X, Hu A, Wu Y, Zhang P, Yang X J Vet Med Sci. 2020; 83(3):549-557.

PMID: 33116004 PMC: 8025435. DOI: 10.1292/jvms.19-0584.

Endoplasmic reticulum stress and pulmonary hypertension.

Hu Y, Yang W, Xie L, Liu T, Liu H, Liu B Pulm Circ. 2020; 10(1):2045894019900121.

PMID: 32110387 PMC: 7000863. DOI: 10.1177/2045894019900121.

Liraglutide Increases VEGF Expression CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury.

Liu C, Liu Y, He J, Mu R, Di Y, Shen N Front Pharmacol. 2019; 10:789.

PMID: 31396081 PMC: 6664686. DOI: 10.3389/fphar.2019.00789.