The Use of Dermal Substitutes in Burn Surgery: Acute Phase

Overview

Journal Wound Repair Regen

Date 2014 Jan 8

PMID 24393152

Citations 65

Authors

Shahriar Shahrokhi

Anna Arno

Marc G Jeschke

Affiliations

Soon will be listed here.

Abstract

Major burns represent a challenge in autologous skin coverage and may lead to severe functional and cosmetic sequelae. Dermal substitutes are increasingly becoming an essential part of burn care during the acute phase of treatment. In the long term dermal substitutes improve functional and cosmetic results and thus enhance quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and defects. Despite the potential of dermal substitutes, further research is required to strengthen scientific evidence regarding their effects and also to develop new technologies and products. Furthermore, dermal substitutes have a pivotal role in future research strategies as they have the potential to provide adequate scaffold for stem cells, tissue engineering, and regenerative medicine with conceivable application of obtaining long-lasting and scarless artificial skin. This review discusses the status quo of dermal substitutes and novel strategies in the use of dermal substitutes with a focus on burn care.

Citing Articles

Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review.

Dean J, Hoch C, Wollenberg B, Navidzadeh J, Maheta B, Mandava A Front Bioeng Biotechnol. 2025; 12():1461328.

PMID: 39840132 PMC: 11747595. DOI: 10.3389/fbioe.2024.1461328.

Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.

van den Bosch A, Verwilligen R, Pijpe A, Jansen L, van der Vlies C, van Eck M Wound Repair Regen. 2024; 33(1):e13248.

PMID: 39727218 PMC: 11672668. DOI: 10.1111/wrr.13248.

Efficacy and Complications Associated with Acellular Dermal Substitute Use in the Treatment of Acute Burns: A Systematic Review and Meta-Analysis.

Press I, Moiemen N, Ahmed Z Eur Burn J. 2024; 4(4):548-562.

PMID: 39600025 PMC: 11571822. DOI: 10.3390/ebj4040036.

Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.

Derman I, Rivera T, Garriga Cerda L, Singh Y, Saini S, Abaci H Int J Extrem Manuf. 2024; 7(1):012009.

PMID: 39569402 PMC: 11574952. DOI: 10.1088/2631-7990/ad878c.

Use of Dermal Substrate for the Treatment of Pediatric Deep Partial-Thickness Burns.

Bergus K, Schwartz D, Patterson K, Srinivas S, Fabia R, Thakkar R Eplasty. 2024; 24:e54.

PMID: 39473999 PMC: 11520366.

References

Wainwright D . Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns. 1995; 21(4):243-8. DOI: 10.1016/0305-4179(95)93866-i. View

Yannas I, Burke J, Gordon P, Huang C, Rubenstein R . Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res. 1980; 14(2):107-32. DOI: 10.1002/jbm.820140203. View

Phillips T . Biologic skin substitutes. J Dermatol Surg Oncol. 1993; 19(8):794-800. DOI: 10.1111/j.1524-4725.1993.tb00426.x. View

Andreadis S, Hamoen K, Yarmush M, Morgan J . Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system. FASEB J. 2001; 15(6):898-906. DOI: 10.1096/fj.00-0324com. View

Muangman P, Engrav L, Heimbach D, Harunari N, Honari S, Gibran N . Complex wound management utilizing an artificial dermal matrix. Ann Plast Surg. 2006; 57(2):199-202. DOI: 10.1097/01.sap.0000218636.61803.d6. View

Ge L, Zheng S, Wei H . Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM. Burns. 2008; 35(1):46-50. DOI: 10.1016/j.burns.2008.05.007. View

Purdue G, Hunt J, Still Jr J, Law E, Herndon D, Goldfarb I . A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. J Burn Care Rehabil. 1997; 18(1 Pt 1):52-7. DOI: 10.1097/00004630-199701000-00009. View

Boyce S . Cultured skin substitutes: a review. Tissue Eng. 2009; 2(4):255-66. DOI: 10.1089/ten.1996.2.255. View

Nguyen D, Potokar T, Price P . An objective long-term evaluation of Integra (a dermal skin substitute) and split thickness skin grafts, in acute burns and reconstructive surgery. Burns. 2009; 36(1):23-8. DOI: 10.1016/j.burns.2009.07.011. View

10.

Myers S, Partha V, Soranzo C, Price R, Navsaria H . Hyalomatrix: a temporary epidermal barrier, hyaluronan delivery, and neodermis induction system for keratinocyte stem cell therapy. Tissue Eng. 2007; 13(11):2733-41. DOI: 10.1089/ten.2007.0109. View

11.

Murray R, Gordin E, Saigal K, Leventhal D, Krein H, Heffelfinger R . Reconstruction of the radial forearm free flap donor site using integra artificial dermis. Microsurgery. 2010; 31(2):104-8. DOI: 10.1002/micr.20833. View

12.

Dantzer E, Queruel P, Salinier L, Palmier B, Quinot J . Dermal regeneration template for deep hand burns: clinical utility for both early grafting and reconstructive surgery. Br J Plast Surg. 2003; 56(8):764-74. DOI: 10.1016/s0007-1226(03)00366-7. View

13.

Shores J, Gabriel A, Gupta S . Skin substitutes and alternatives: a review. Adv Skin Wound Care. 2007; 20(9 Pt 1):493-508. DOI: 10.1097/01.ASW.0000288217.83128.f3. View

14.

Bello Y, Falabella A, Eaglstein W . Tissue-engineered skin. Current status in wound healing. Am J Clin Dermatol. 2001; 2(5):305-13. DOI: 10.2165/00128071-200102050-00005. View

15.

Ryssel H, Gazyakan E, Germann G, Ohlbauer M . The use of MatriDerm in early excision and simultaneous autologous skin grafting in burns--a pilot study. Burns. 2007; 34(1):93-7. DOI: 10.1016/j.burns.2007.01.018. View

16.

Ruszczak Z . Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev. 2003; 55(12):1595-611. DOI: 10.1016/j.addr.2003.08.003. View

17.

Rennekampff H . [Skin graft procedures in burn surgery]. Unfallchirurg. 2009; 112(6):543-9. DOI: 10.1007/s00113-009-1655-5. View

18.

Gravante G, Delogu D, Giordan N, Morano G, Montone A, Esposito G . The use of Hyalomatrix PA in the treatment of deep partial-thickness burns. J Burn Care Res. 2007; 28(2):269-74. DOI: 10.1097/BCR.0B013E318031A236. View

19.

van der Veen V, Boekema B, Ulrich M, Middelkoop E . New dermal substitutes. Wound Repair Regen. 2011; 19 Suppl 1:s59-65. DOI: 10.1111/j.1524-475X.2011.00713.x. View

20.

Ralston D, Layton C, Dalley A, Boyce S, Freedlander E, Mac Neil S . The requirement for basement membrane antigens in the production of human epidermal/dermal composites in vitro. Br J Dermatol. 1999; 140(4):605-15. DOI: 10.1046/j.1365-2133.1999.02758.x. View