Prevalence of Transient Congenital Hypothyroidism in Central Part of Iran

Overview

Journal J Res Med Sci

Specialty General Medicine

Date 2014 Jan 1

PMID 24379847

Citations 17

Authors

Mahmoud Ghasemi

Mahin Hashemipour

Silva Hovsepian

Kamal Heiydari

Ali Sajadi

Rezvaneh Hadian

Marjan Mansourian

Naghme Mirshahzadeh

Marzie Dalvi

Affiliations

Soon will be listed here.

Abstract

Background: Congenital hypothyroidism (CH) considered a common endocrine disorder in Iran. We report the epidemiologic findings of CH screening program in Isfahan, seven years after its development, regarding the prevalence of transient CH (TCH) and its screening properties comparing with permanent CH (PCH).

Materials And Methods: In this cross-sectional study, children with primary diagnosis of CH were studied. Considering screening and follow-up lab data and the decision of pediatric endocrinologists, the final diagnosis of TCH was determined.

Results: A total of 464,648 neonates were screened. The coverage percent of the CH screening and recall rate was 98.9 and 2.1%, respectively. Out of which, 1,990 neonates were diagnosed with primary CH. TCH was diagnosed in 1,580 neonates. The prevalence of TCH was 1 in 294 live births. 79.4% of patients with primary CH had TCH. Mean of screening (54.7 ± 59.0 in PCH vs 21.8 ± 28.9 in TCH), recall (56.5 ± 58.8 in PCH vs 36.6 ± 45.0 in TCH), and thyroid stimulating hormone (TSH) and mean of TSH before (2.0 ± 2.9 in PCH vs 1.6 ± 1.6 in TCH) and after (37.7 ± 29.5 in PCH vs 4.3 ± 1.9 in TCH) discontinuing treatment at 3 years of age was significantly higher in PCH than TCH (P < 0.0000).

Conclusion: The higher rate of CH in Isfahan is mainly due to the transient form of the disease. Further studies for evaluating the role of other environmental, autoimmune and/or genetic factors in the pathophysiology of the disease is warranted.

Citing Articles

The natural course of newborns with transient congenital hypothyroidism.

Almagor T, Almashanu S, Elias-Assad G, Admoni O, Ludar H, London S Endocr Connect. 2024; 13(12).

PMID: 39413214 PMC: 11623249. DOI: 10.1530/EC-24-0316.

High frequency of transient congenital hypothyroidism among infants referred for suspected congenital hypothyroidism from the Turkish National screening program: thyroxine dose may guide the prediction of transients.

Ozer Y, Anik A, Sayili U, Tercan U, Deveci Sevim R, Gunes S J Endocrinol Invest. 2024; 47(9):2213-2224.

PMID: 38546931 PMC: 11369008. DOI: 10.1007/s40618-024-02348-9.

Etiological, clinical, and laboratory evaluation of congenital hypothyroidism and determination of levothyroxine (LT4) dose at treatment interruption in differentiating permanent vs. transient patients.

Dundar I, Buyukavci M, Ciftci N Turk J Med Sci. 2023; 52(6):1863-1871.

PMID: 36945978 PMC: 10390198. DOI: 10.55730/1300-0144.5533.

Physical Development at School Entry in Children with Congenital Hypothyroidism Diagnosed by the National Program of Newborn Screening in Iran.

Yarahmadi S, Nikkhoo B, Parvizi H, Motaghi R, Rahmani K Int J Endocrinol Metab. 2023; 21(1):e131081.

PMID: 36945342 PMC: 10024811. DOI: 10.5812/ijem-131081.

MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism.

Peters C, Schoenmakers N Eur J Endocrinol. 2022; 187(2):R1-R16.

PMID: 35588090 PMC: 9254299. DOI: 10.1530/EJE-21-1278.

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