Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 Neonates

Overview

Journal Horm Res

Specialty Endocrinology

Date 2004 Jul 9

PMID 15237248

Citations 32

Authors

Mahin Hashemipour

Massoud Amini

Ramin Iranpour

Gholam Hossein Sadri

Narges Javaheri

Sassan Haghighi

Silva Hovsepian

Abbas Ali Javadi

Mahdi Nematbakhsh

Goshtasb Sattari

Affiliations

Soon will be listed here.

Abstract

Aims: To evaluate the prevalence of congenital hypothyroidism (CH) in a screening program performed for the first time in Isfahan, Iran.

Methods: From May 2002 to December 2002, T4 and TSH serum concentrations of 20,000 3- to 7-day-old newborns, born in all 17 hospitals of the city, were measured by radioimmunoassay and immunoradiometric assay, respectively. The newborns with abnormal screening results (TSH >20 mIU/l, T4 <6.5 microg/dl and based on the weight) were re-examined.

Results: Of 531 recalled subjects (recall rate 2.6%), 54 were confirmed to be hypothyroid, showing a prevalence of 1:370 for CH.

Conclusion: Considering the high frequency of CH, the necessity of implementing a routine screening program in the healthcare system of Isfahan Province is emphasized.

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