Experimental Sleep Deprivation As a Tool to Test Memory Deficits in Rodents

Overview

Journal Front Syst Neurosci

Specialty Neurology

Date 2014 Jan 1

PMID 24379759

Citations 56

Authors

Valeria Colavito

Paolo F Fabene

Gigliola Grassi-Zucconi

Fabien Pifferi

Yves Lamberty

Marina Bentivoglio

Giuseppe Bertini

Affiliations

Soon will be listed here.

Abstract

Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and mice) are here reviewed. The vast majority of these studies have been aimed at understanding the contribution of sleep to cognition, and in particular to memory. Relatively little attention, instead, has been devoted to SD as a challenge to induce a transient memory impairment, and therefore as a tool to test cognitive enhancers in drug discovery. Studies that have accurately described methodological aspects of the SD protocol are first reviewed, followed by procedures to investigate SD-induced impairment of learning and memory consolidation in order to propose SD protocols that could be employed as cognitive challenge. Thus, a platform of knowledge is provided for laboratory protocols that could be used to assess the efficacy of drugs designed to improve memory performance in rodents, including rodent models of neurodegenerative diseases that cause cognitive deficits, and Alzheimer's disease in particular. Issues in the interpretation of such preclinical data and their predictive value for clinical translation are also discussed.

Citing Articles

Adolescent sleep and its disruption in depression and anxiety.

Chai R, Bian W Front Neurosci. 2024; 18:1479420.

PMID: 39575099 PMC: 11578994. DOI: 10.3389/fnins.2024.1479420.

Influence of sleep on physiological systems in atherosclerosis.

Kiss M, Cohen O, McAlpine C, Swirski F Nat Cardiovasc Res. 2024; 3(11):1284-1300.

PMID: 39528718 PMC: 11567060. DOI: 10.1038/s44161-024-00560-7.

Enhanced homeostatic sleep response and decreased neurodegenerative proteins in cereblon knock-out mice.

Jung J, Kim J, Akber U, Lee N, Baek J, Jung J Commun Biol. 2024; 7(1):1218.

PMID: 39349747 PMC: 11442454. DOI: 10.1038/s42003-024-06879-y.

Sleep induced by mechanosensory stimulation provides cognitive and health benefits in .

Inami S, Koh K bioRxiv. 2024; .

PMID: 39026689 PMC: 11257551. DOI: 10.1101/2024.07.10.602891.

Sleep loss diminishes hippocampal reactivation and replay.

Giri B, Kinsky N, Kaya U, Maboudi K, Abel T, Diba K Nature. 2024; 630(8018):935-942.

PMID: 38867049 PMC: 11472378. DOI: 10.1038/s41586-024-07538-2.

References

Silva R, Chehin A, Kameda S, Takatsu-Coleman A, Abilio V, Tufik S . Effects of pre- or post-training paradoxical sleep deprivation on two animal models of learning and memory in mice. Neurobiol Learn Mem. 2004; 82(2):90-8. DOI: 10.1016/j.nlm.2004.04.005. View

Westerman M, Mariash A, Kotilinek L, Kawarabayashi T, Younkin L, Carlson G . The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002; 22(5):1858-67. PMC: 6758862. View

Chang H, Wu U, Lan C . Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. J Pineal Res. 2009; 47(3):211-20. DOI: 10.1111/j.1600-079X.2009.00704.x. View

Walsh C, Booth V, Poe G . Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following training. Learn Mem. 2011; 18(7):422-34. PMC: 3125613. DOI: 10.1101/lm.2099011. View

Leemburg S, Vyazovskiy V, Olcese U, Bassetti C, Tononi G, Cirelli C . Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A. 2010; 107(36):15939-44. PMC: 2936639. DOI: 10.1073/pnas.1002570107. View

Smith C, Rose G . Posttraining paradoxical sleep in rats is increased after spatial learning in the Morris water maze. Behav Neurosci. 1998; 111(6):1197-204. DOI: 10.1037//0735-7044.111.6.1197. View

Radulovic J, Tronson N . Molecular specificity of multiple hippocampal processes governing fear extinction. Rev Neurosci. 2010; 21(1):1-17. PMC: 2922903. DOI: 10.1515/revneuro.2010.21.1.1. View

Kitahama K, Valatx J, Jouvet M . Paradoxical sleep deprivation and performance of an active avoidance task: impairment of c57BR mice and no effect in c57BL/6 mice. Physiol Behav. 1981; 27(1):41-50. DOI: 10.1016/0031-9384(81)90297-3. View

Moreira K, Ferreira T, Hipolide D, Fornari R, Tufik S, Oliveira M . Modafinil prevents inhibitory avoidance memory deficit induced by sleep deprivation in rats. Sleep. 2010; 33(7):990-3. PMC: 2894442. DOI: 10.1093/sleep/33.7.990. View

10.

Winocur G, Moscovitch M . Anterograde and retrograde amnesia after lesions to frontal cortex in rats. J Neurosci. 1999; 19(21):9611-7. PMC: 6782922. View

11.

Legault G, Delay S, Madore A . Identification of a rapid eye movement sleep window for learning of the win-shift radial arm maze task for male Sprague-Dawley rats. J Sleep Res. 2010; 19(4):508-15. DOI: 10.1111/j.1365-2869.2010.00842.x. View

12.

Guan Z, Peng X, Fang J . Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus. Brain Res. 2004; 1018(1):38-47. DOI: 10.1016/j.brainres.2004.05.032. View

13.

Dametto M, Suchecki D, Bueno O, Moreira K, Tufik S, Oliveira M . Social stress does not interact with paradoxical sleep deprivation-induced memory impairment. Behav Brain Res. 2002; 129(1-2):171-8. DOI: 10.1016/s0166-4328(01)00345-x. View

14.

Youngblood B, Zhou J, Smagin G, Ryan D, Harris R . Sleep deprivation by the "flower pot" technique and spatial reference memory. Physiol Behav. 1997; 61(2):249-56. DOI: 10.1016/s0031-9384(96)00363-0. View

15.

Ward C, McCarley R, Strecker R . Experimental sleep fragmentation impairs spatial reference but not working memory in Fischer/Brown Norway rats. J Sleep Res. 2009; 18(2):238-44. PMC: 2721795. DOI: 10.1111/j.1365-2869.2008.00714.x. View

16.

Wesensten N, Killgore W, Balkin T . Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation. J Sleep Res. 2005; 14(3):255-66. DOI: 10.1111/j.1365-2869.2005.00468.x. View

17.

Killgore W, Kahn-Greene E, Grugle N, Killgore D, Balkin T . Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil. Sleep. 2009; 32(2):205-16. PMC: 2635585. DOI: 10.1093/sleep/32.2.205. View

18.

Dodds C, Bullmore E, Henson R, Christensen S, Miller S, Smith M . Effects of donepezil on cognitive performance after sleep deprivation. Hum Psychopharmacol. 2011; 26(8):578-87. DOI: 10.1002/hup.1248. View

19.

Revel F, Gottowik J, Gatti S, Wettstein J, Moreau J . Rodent models of insomnia: a review of experimental procedures that induce sleep disturbances. Neurosci Biobehav Rev. 2009; 33(6):874-99. DOI: 10.1016/j.neubiorev.2009.03.002. View

20.

Palchykova S, Winsky-Sommerer R, Meerlo P, Durr R, Tobler I . Sleep deprivation impairs object recognition in mice. Neurobiol Learn Mem. 2006; 85(3):263-71. DOI: 10.1016/j.nlm.2005.11.005. View