Microglial TNFα Controls Daily Changes in Synaptic GABAARs and Sleep Slow Waves

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2024 May 2

PMID 38695719

Authors

Maria Joana Pinto

Lucy Bizien

Julie M J Fabre

Nina ukanovic

Valentin Lepetz

Fiona Henderson

Marine Pujol

Romain W Sala

Thibault Tarpin

Daniela Popa

Antoine Triller

Clement Lena

Veronique Fabre

Alain Bessis

Affiliations

Soon will be listed here.

Abstract

Microglia sense the changes in their environment. How microglia actively translate these changes into suitable cues to adapt brain physiology is unknown. We reveal an activity-dependent regulation of cortical inhibitory synapses by microglia, driven by purinergic signaling acting on P2RX7 and mediated by microglia-derived TNFα. We demonstrate that sleep induces microglia-dependent synaptic enrichment of GABAARs in a manner dependent on microglial TNFα and P2RX7. We further show that microglia-specific depletion of TNFα alters slow waves during NREM sleep and blunt memory consolidation in sleep-dependent learning tasks. Together, our results reveal that microglia orchestrate sleep-intrinsic plasticity of synaptic GABAARs, sculpt sleep slow waves, and support memory consolidation.

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