High-field Small Animal Magnetic Resonance Oncology Studies

Overview

Journal Phys Med Biol

Publisher IOP Publishing

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2013 Dec 31

PMID 24374985

Citations 5

Authors

Louisa Bokacheva

Ellen Ackerstaff

H Carl LeKaye

Kristen Zakian

Jason A Koutcher

Affiliations

Soon will be listed here.

Abstract

This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High-field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include (1)H, (31)P, chemical exchange saturation transfer imaging and hyperpolarized (13)C MRS as well as diffusion-weighted, blood oxygen level dependent contrast imaging and dynamic contrast-enhanced MRI. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.

Citing Articles

Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial.

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Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas.

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Yun B, Cho N, Li M, Jang M, Park S, Kang H Korean J Radiol. 2014; 15(5):591-604.

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